Surface-modified magnetite nanoparticles for hyperthermia: Preparation, characterization, and cytotoxicity studies

D. H. Kim; S. H. Lee; K. H. Im; K. N. Kim; K. M. Kim; I. B. Shim; M. H. Lee; Y. K. Lee

doi:10.1016/j.cap.2006.01.048

Surface-modified magnetite nanoparticles for hyperthermia: Preparation, characterization, and cytotoxicity studies

D. H. Kim, S. H. Lee, K. H. Im, K. N. Kim, K. M. Kim, I. B. Shim, M. H. Lee, Y. K. Lee

Department of Dental Biomaterials and Bioengineering

Research output: Contribution to journal › Article

82 Citations (Scopus)

Abstract

Biocompatible magnetic nanoparticles could be selected for smart hyperthermia. The magnetic particles should have a narrow size distribution and surface modified with biocompatible materials. In this study, the effects of surface modification in nano-magnetite were evaluated by characterization and cell response. The synthesized magnetite exhibited a mean diameter of 10.3 ± 2.6 nm. The temperature change under alternating magnetic field and saturation magnetization (M_s) was ΔT = 23 °C, M_s = 25.6 emu/g and ΔT = 12 °C, M_s = 16.4 emu/g in chitosan and starch coated magnetite, respectively. In cytotoxic test, the viability of L929 cells was the greatest value 93.67% in chitosan coated magnetic particles. The exothermic and biocompatible chitosan coated magnetite will be selected for optimized hyperthermic thermoseed.

Original language	English
Pages (from-to)	e242-e246
Journal	Current Applied Physics
Volume	6
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/j.cap.2006.01.048
Publication status	Published - 2006 Aug

All Science Journal Classification (ASJC) codes

Materials Science(all)
Physics and Astronomy(all)

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10.1016/j.cap.2006.01.048

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Kim, D. H., Lee, S. H., Im, K. H., Kim, K. N., Kim, K. M., Shim, I. B., Lee, M. H., & Lee, Y. K. (2006). Surface-modified magnetite nanoparticles for hyperthermia: Preparation, characterization, and cytotoxicity studies. Current Applied Physics, 6(SUPPL. 1), e242-e246. https://doi.org/10.1016/j.cap.2006.01.048

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title = "Surface-modified magnetite nanoparticles for hyperthermia: Preparation, characterization, and cytotoxicity studies",

abstract = "Biocompatible magnetic nanoparticles could be selected for smart hyperthermia. The magnetic particles should have a narrow size distribution and surface modified with biocompatible materials. In this study, the effects of surface modification in nano-magnetite were evaluated by characterization and cell response. The synthesized magnetite exhibited a mean diameter of 10.3 ± 2.6 nm. The temperature change under alternating magnetic field and saturation magnetization (Ms) was ΔT = 23 °C, Ms = 25.6 emu/g and ΔT = 12 °C, Ms = 16.4 emu/g in chitosan and starch coated magnetite, respectively. In cytotoxic test, the viability of L929 cells was the greatest value 93.67% in chitosan coated magnetic particles. The exothermic and biocompatible chitosan coated magnetite will be selected for optimized hyperthermic thermoseed.",

author = "Kim, {D. H.} and Lee, {S. H.} and Im, {K. H.} and Kim, {K. N.} and Kim, {K. M.} and Shim, {I. B.} and Lee, {M. H.} and Lee, {Y. K.}",

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T2 - Preparation, characterization, and cytotoxicity studies

AU - Kim, D. H.

AU - Lee, S. H.

AU - Im, K. H.

AU - Kim, K. N.

AU - Kim, K. M.

AU - Shim, I. B.

AU - Lee, M. H.

AU - Lee, Y. K.

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AB - Biocompatible magnetic nanoparticles could be selected for smart hyperthermia. The magnetic particles should have a narrow size distribution and surface modified with biocompatible materials. In this study, the effects of surface modification in nano-magnetite were evaluated by characterization and cell response. The synthesized magnetite exhibited a mean diameter of 10.3 ± 2.6 nm. The temperature change under alternating magnetic field and saturation magnetization (Ms) was ΔT = 23 °C, Ms = 25.6 emu/g and ΔT = 12 °C, Ms = 16.4 emu/g in chitosan and starch coated magnetite, respectively. In cytotoxic test, the viability of L929 cells was the greatest value 93.67% in chitosan coated magnetic particles. The exothermic and biocompatible chitosan coated magnetite will be selected for optimized hyperthermic thermoseed.

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