Abstract
Biocompatible magnetic nanoparticles could be selected for smart hyperthermia. The magnetic particles should have a narrow size distribution and surface modified with biocompatible materials. In this study, the effects of surface modification in nano-magnetite were evaluated by characterization and cell response. The synthesized magnetite exhibited a mean diameter of 10.3 ± 2.6 nm. The temperature change under alternating magnetic field and saturation magnetization (Ms) was ΔT = 23 °C, Ms = 25.6 emu/g and ΔT = 12 °C, Ms = 16.4 emu/g in chitosan and starch coated magnetite, respectively. In cytotoxic test, the viability of L929 cells was the greatest value 93.67% in chitosan coated magnetic particles. The exothermic and biocompatible chitosan coated magnetite will be selected for optimized hyperthermic thermoseed.
Original language | English |
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Pages (from-to) | e242-e246 |
Journal | Current Applied Physics |
Volume | 6 |
Issue number | SUPPL. 1 |
DOIs | |
Publication status | Published - 2006 Aug |
Bibliographical note
Funding Information:This work was supported by Grant No. R13-2003-13 from the Medical Science and Engineering Research Program of the Korea Science & Engineering Foundation.
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Physics and Astronomy(all)