Abstract
Biocompatible magnetic nanoparticles could be selected for smart hyperthermia. The magnetic particles should have a narrow size distribution and surface modified with biocompatible materials. In this study, the effects of surface modification in nano-magnetite were evaluated by characterization and cell response. The synthesized magnetite exhibited a mean diameter of 10.3 ± 2.6 nm. The temperature change under alternating magnetic field and saturation magnetization (Ms) was ΔT = 23 °C, Ms = 25.6 emu/g and ΔT = 12 °C, Ms = 16.4 emu/g in chitosan and starch coated magnetite, respectively. In cytotoxic test, the viability of L929 cells was the greatest value 93.67% in chitosan coated magnetic particles. The exothermic and biocompatible chitosan coated magnetite will be selected for optimized hyperthermic thermoseed.
| Original language | English |
|---|---|
| Pages (from-to) | e242-e246 |
| Journal | Current Applied Physics |
| Volume | 6 |
| Issue number | SUPPL. 1 |
| DOIs | |
| Publication status | Published - 2006 Aug 1 |
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All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Physics and Astronomy(all)
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Surface-modified magnetite nanoparticles for hyperthermia : Preparation, characterization, and cytotoxicity studies. / Kim, D. H.; Lee, S. H.; Im, K. H.; Kim, K. N.; Kim, K. M.; Shim, I. B.; Lee, M. H.; Lee, Y. K.
In: Current Applied Physics, Vol. 6, No. SUPPL. 1, 01.08.2006, p. e242-e246.Research output: Contribution to journal › Article
TY - JOUR
T1 - Surface-modified magnetite nanoparticles for hyperthermia
T2 - Preparation, characterization, and cytotoxicity studies
AU - Kim, D. H.
AU - Lee, S. H.
AU - Im, K. H.
AU - Kim, K. N.
AU - Kim, K. M.
AU - Shim, I. B.
AU - Lee, M. H.
AU - Lee, Y. K.
PY - 2006/8/1
Y1 - 2006/8/1
N2 - Biocompatible magnetic nanoparticles could be selected for smart hyperthermia. The magnetic particles should have a narrow size distribution and surface modified with biocompatible materials. In this study, the effects of surface modification in nano-magnetite were evaluated by characterization and cell response. The synthesized magnetite exhibited a mean diameter of 10.3 ± 2.6 nm. The temperature change under alternating magnetic field and saturation magnetization (Ms) was ΔT = 23 °C, Ms = 25.6 emu/g and ΔT = 12 °C, Ms = 16.4 emu/g in chitosan and starch coated magnetite, respectively. In cytotoxic test, the viability of L929 cells was the greatest value 93.67% in chitosan coated magnetic particles. The exothermic and biocompatible chitosan coated magnetite will be selected for optimized hyperthermic thermoseed.
AB - Biocompatible magnetic nanoparticles could be selected for smart hyperthermia. The magnetic particles should have a narrow size distribution and surface modified with biocompatible materials. In this study, the effects of surface modification in nano-magnetite were evaluated by characterization and cell response. The synthesized magnetite exhibited a mean diameter of 10.3 ± 2.6 nm. The temperature change under alternating magnetic field and saturation magnetization (Ms) was ΔT = 23 °C, Ms = 25.6 emu/g and ΔT = 12 °C, Ms = 16.4 emu/g in chitosan and starch coated magnetite, respectively. In cytotoxic test, the viability of L929 cells was the greatest value 93.67% in chitosan coated magnetic particles. The exothermic and biocompatible chitosan coated magnetite will be selected for optimized hyperthermic thermoseed.
UR - http://www.scopus.com/inward/record.url?scp=33746238839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746238839&partnerID=8YFLogxK
U2 - 10.1016/j.cap.2006.01.048
DO - 10.1016/j.cap.2006.01.048
M3 - Article
AN - SCOPUS:33746238839
VL - 6
SP - e242-e246
JO - Current Applied Physics
JF - Current Applied Physics
SN - 1567-1739
IS - SUPPL. 1
ER -