Surface modulation of magnetic nanocrystals in the development of highly efficient magnetic resonance probes for intracellular labeling

Ho Taek Song, Jin Sil Choi, Yong Min Huh, Sungjun Kim, Young Wook Jun, Jin Suck Sun, Jinwoo Cheon

Research output: Contribution to journalArticle

277 Citations (Scopus)

Abstract

High-quality biocompatible magnetic iron oxide (Fe3O4) nanocrystals were developed through a ligand exchange process of hydrophobically capped nanocrystals with hydrophilic molecules. By simple modulation of the nanocrystal surface ligand charge properties, we have been able to prepare magnetic nanocrystals with excellent intracellular labeling capabilities that efficiently label a variety of cell types without the need for additional transport facilitating agents. The excellent intracellular labeling capability of the newly developed cationic WSIO has further led to successful MRI monitoring of the migration of neural stem cells in rat spinal cord. The magnetic nanocrystals developed here have great potential in applications for labeling of various cell types and also the monitoring of cell-based medical treatments and cancer metastasis.

Original languageEnglish
Pages (from-to)9992-9993
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number28
DOIs
Publication statusPublished - 2005 Jul 20

Fingerprint

Magnetic resonance
Nanoparticles
Nanocrystals
Labeling
Magnetic Resonance Spectroscopy
Modulation
Ligands
Neural Stem Cells
Monitoring
Stem cells
Iron oxides
Magnetic resonance imaging
Rats
Labels
Spinal Cord
Neoplasm Metastasis
Molecules
Neoplasms

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

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abstract = "High-quality biocompatible magnetic iron oxide (Fe3O4) nanocrystals were developed through a ligand exchange process of hydrophobically capped nanocrystals with hydrophilic molecules. By simple modulation of the nanocrystal surface ligand charge properties, we have been able to prepare magnetic nanocrystals with excellent intracellular labeling capabilities that efficiently label a variety of cell types without the need for additional transport facilitating agents. The excellent intracellular labeling capability of the newly developed cationic WSIO has further led to successful MRI monitoring of the migration of neural stem cells in rat spinal cord. The magnetic nanocrystals developed here have great potential in applications for labeling of various cell types and also the monitoring of cell-based medical treatments and cancer metastasis.",
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Surface modulation of magnetic nanocrystals in the development of highly efficient magnetic resonance probes for intracellular labeling. / Song, Ho Taek; Choi, Jin Sil; Huh, Yong Min; Kim, Sungjun; Jun, Young Wook; Sun, Jin Suck; Cheon, Jinwoo.

In: Journal of the American Chemical Society, Vol. 127, No. 28, 20.07.2005, p. 9992-9993.

Research output: Contribution to journalArticle

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AU - Song, Ho Taek

AU - Choi, Jin Sil

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AU - Sun, Jin Suck

AU - Cheon, Jinwoo

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