Surface plasmon-enhanced nanoscopy of intracellular cytoskeletal actin filaments using random nanodot arrays

Youngjin Oh, Taehwang Son, Sook Young Kim, Wonju Lee, Heejin Yang, Jong Ryul Choi, Jeon Soo Shin, Donghyun Kim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The feasibility of super-resolution microscopy has been investigated based on random localization of surface plasmon using blocked random nanodot arrays. The resolution is mainly determined by the size of localized fields in the range of 100-150 nm. The concept was validated by imaging FITC-conjugated phalloidin that binds to cellular actin filaments. The experimental results confirm improved resolution in reconstructed images. Effect of far-field registration on image reconstruction was also analyzed. Correlation between reconstructed images was maintained to be above 81% after registration. Nanodot arrays are synthesized by temperature-annealing without sophisticated lithography and thus can be mass-produced in an extremely large substrate. The results suggest a superresolution imaging technique that can be accessible and available in large amounts.

Original languageEnglish
Pages (from-to)27695-27706
Number of pages12
JournalOptics Express
Volume22
Issue number22
DOIs
Publication statusPublished - 2014 Jan 1

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

Fingerprint Dive into the research topics of 'Surface plasmon-enhanced nanoscopy of intracellular cytoskeletal actin filaments using random nanodot arrays'. Together they form a unique fingerprint.

  • Cite this