Surgical outcome and prognostic factors influencing visual acuity in myopic foveoschisis patients

Dong Hyun Lee, Inhee Moon, Hyun Goo Kang, Eun Young Choi, Sung Soo Kim, Suk Ho Byeon, Hyoung Jun Koh, Sung Chul Lee, Min Kim

Research output: Contribution to journalArticle

Abstract

Background: To analyze the optical coherence tomography (OCT) characteristics and visual outcome of vitrectomy in myopic foveoschisis (MF) patients and identify prognostic factors. Methods: This study is a retrospective clinical cohort study in tertiary care hospital. Thirty-two eyes of 32 patients who underwent MF-related vitrectomy in were investigated retrospectively. Best-corrected visual acuity (BCVA) measured at 1 year post surgery and changes in central foveal thickness (CFT) and co-existing macular pathologies, such as foveal detachment (FD), lamellar holes, and macular holes were the main outcome measures. Prognostic factors were identified using multivariate linear regression analysis. Results: Average BCVA (in logarithm of the minimum angle of resolution) and mean CFT had improved from 0.46 ± 0.06 to 0.37 ± 0.07 (P = 0.089) and from 485.72 ± 164.69 to 341.71 ± 109.70 (P < 0.001), respectively. Univariate analysis identified baseline BCVA, epiretinal membrane, no coexisting OCT features other than MF, FD on OCT, and gas injection as significantly associated with visual outcome (P < 0.001, 0.014, 0.022, < 0.001, and 0.030). Better baseline BCVA and absence of FD on OCT remained significant (P < 0.001 and < 0.001, respectively) after multivariate analysis. Conclusion: Good preoperative visual acuity and absence of FD pre-surgery are important predictors of good visual prognosis. Thus, timely surgical intervention, before development of macular complications, may improve visual outcome after surgical treatment of patients with MF.

Original languageEnglish
Pages (from-to)1642-1648
Number of pages7
JournalEye (Basingstoke)
Volume33
Issue number10
DOIs
Publication statusPublished - 2019 Oct 1

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Visual Acuity
Optical Coherence Tomography
Vitrectomy
Epiretinal Membrane
Retinal Perforations
Tertiary Healthcare
Tertiary Care Centers
Linear Models
Cohort Studies
Multivariate Analysis
Gases
Regression Analysis
Outcome Assessment (Health Care)
Pathology
Injections
Therapeutics

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems

Cite this

Lee, D. H., Moon, I., Kang, H. G., Choi, E. Y., Kim, S. S., Byeon, S. H., ... Kim, M. (2019). Surgical outcome and prognostic factors influencing visual acuity in myopic foveoschisis patients. Eye (Basingstoke), 33(10), 1642-1648. https://doi.org/10.1038/s41433-019-0462-7
Lee, Dong Hyun ; Moon, Inhee ; Kang, Hyun Goo ; Choi, Eun Young ; Kim, Sung Soo ; Byeon, Suk Ho ; Koh, Hyoung Jun ; Lee, Sung Chul ; Kim, Min. / Surgical outcome and prognostic factors influencing visual acuity in myopic foveoschisis patients. In: Eye (Basingstoke). 2019 ; Vol. 33, No. 10. pp. 1642-1648.
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abstract = "Background: To analyze the optical coherence tomography (OCT) characteristics and visual outcome of vitrectomy in myopic foveoschisis (MF) patients and identify prognostic factors. Methods: This study is a retrospective clinical cohort study in tertiary care hospital. Thirty-two eyes of 32 patients who underwent MF-related vitrectomy in were investigated retrospectively. Best-corrected visual acuity (BCVA) measured at 1 year post surgery and changes in central foveal thickness (CFT) and co-existing macular pathologies, such as foveal detachment (FD), lamellar holes, and macular holes were the main outcome measures. Prognostic factors were identified using multivariate linear regression analysis. Results: Average BCVA (in logarithm of the minimum angle of resolution) and mean CFT had improved from 0.46 ± 0.06 to 0.37 ± 0.07 (P = 0.089) and from 485.72 ± 164.69 to 341.71 ± 109.70 (P < 0.001), respectively. Univariate analysis identified baseline BCVA, epiretinal membrane, no coexisting OCT features other than MF, FD on OCT, and gas injection as significantly associated with visual outcome (P < 0.001, 0.014, 0.022, < 0.001, and 0.030). Better baseline BCVA and absence of FD on OCT remained significant (P < 0.001 and < 0.001, respectively) after multivariate analysis. Conclusion: Good preoperative visual acuity and absence of FD pre-surgery are important predictors of good visual prognosis. Thus, timely surgical intervention, before development of macular complications, may improve visual outcome after surgical treatment of patients with MF.",
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Lee, DH, Moon, I, Kang, HG, Choi, EY, Kim, SS, Byeon, SH, Koh, HJ, Lee, SC & Kim, M 2019, 'Surgical outcome and prognostic factors influencing visual acuity in myopic foveoschisis patients', Eye (Basingstoke), vol. 33, no. 10, pp. 1642-1648. https://doi.org/10.1038/s41433-019-0462-7

Surgical outcome and prognostic factors influencing visual acuity in myopic foveoschisis patients. / Lee, Dong Hyun; Moon, Inhee; Kang, Hyun Goo; Choi, Eun Young; Kim, Sung Soo; Byeon, Suk Ho; Koh, Hyoung Jun; Lee, Sung Chul; Kim, Min.

In: Eye (Basingstoke), Vol. 33, No. 10, 01.10.2019, p. 1642-1648.

Research output: Contribution to journalArticle

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T1 - Surgical outcome and prognostic factors influencing visual acuity in myopic foveoschisis patients

AU - Lee, Dong Hyun

AU - Moon, Inhee

AU - Kang, Hyun Goo

AU - Choi, Eun Young

AU - Kim, Sung Soo

AU - Byeon, Suk Ho

AU - Koh, Hyoung Jun

AU - Lee, Sung Chul

AU - Kim, Min

PY - 2019/10/1

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N2 - Background: To analyze the optical coherence tomography (OCT) characteristics and visual outcome of vitrectomy in myopic foveoschisis (MF) patients and identify prognostic factors. Methods: This study is a retrospective clinical cohort study in tertiary care hospital. Thirty-two eyes of 32 patients who underwent MF-related vitrectomy in were investigated retrospectively. Best-corrected visual acuity (BCVA) measured at 1 year post surgery and changes in central foveal thickness (CFT) and co-existing macular pathologies, such as foveal detachment (FD), lamellar holes, and macular holes were the main outcome measures. Prognostic factors were identified using multivariate linear regression analysis. Results: Average BCVA (in logarithm of the minimum angle of resolution) and mean CFT had improved from 0.46 ± 0.06 to 0.37 ± 0.07 (P = 0.089) and from 485.72 ± 164.69 to 341.71 ± 109.70 (P < 0.001), respectively. Univariate analysis identified baseline BCVA, epiretinal membrane, no coexisting OCT features other than MF, FD on OCT, and gas injection as significantly associated with visual outcome (P < 0.001, 0.014, 0.022, < 0.001, and 0.030). Better baseline BCVA and absence of FD on OCT remained significant (P < 0.001 and < 0.001, respectively) after multivariate analysis. Conclusion: Good preoperative visual acuity and absence of FD pre-surgery are important predictors of good visual prognosis. Thus, timely surgical intervention, before development of macular complications, may improve visual outcome after surgical treatment of patients with MF.

AB - Background: To analyze the optical coherence tomography (OCT) characteristics and visual outcome of vitrectomy in myopic foveoschisis (MF) patients and identify prognostic factors. Methods: This study is a retrospective clinical cohort study in tertiary care hospital. Thirty-two eyes of 32 patients who underwent MF-related vitrectomy in were investigated retrospectively. Best-corrected visual acuity (BCVA) measured at 1 year post surgery and changes in central foveal thickness (CFT) and co-existing macular pathologies, such as foveal detachment (FD), lamellar holes, and macular holes were the main outcome measures. Prognostic factors were identified using multivariate linear regression analysis. Results: Average BCVA (in logarithm of the minimum angle of resolution) and mean CFT had improved from 0.46 ± 0.06 to 0.37 ± 0.07 (P = 0.089) and from 485.72 ± 164.69 to 341.71 ± 109.70 (P < 0.001), respectively. Univariate analysis identified baseline BCVA, epiretinal membrane, no coexisting OCT features other than MF, FD on OCT, and gas injection as significantly associated with visual outcome (P < 0.001, 0.014, 0.022, < 0.001, and 0.030). Better baseline BCVA and absence of FD on OCT remained significant (P < 0.001 and < 0.001, respectively) after multivariate analysis. Conclusion: Good preoperative visual acuity and absence of FD pre-surgery are important predictors of good visual prognosis. Thus, timely surgical intervention, before development of macular complications, may improve visual outcome after surgical treatment of patients with MF.

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