Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian regions, 2007-2008.

Western Pacific Programme WHO Western Pacific Programme, East Asian Gonococcal Antimicrobial Surveillance Programme South East Asian Gonococcal Antimicrobial Surveillance Programme, J. W. Tapsall, E. A. Limnios, Hjh Mahani Hj Abu Bakar, Brunei Darussalam, Yin Yue Ping, E. M. Buadromo, P. Kumar, S. Singh, J. Lo, M. Bala, A. Risbud, T. Deguchi, M. Tanaka, Y. Watanabe, Kyungwon Lee, Y. Chong, S. Noikaseumsy, T. PhouthavaneI. Ching Sam, O. Tundev, K. M. Lwin, P. H. Eh, C. Goorant, R. Goursaud, T. Bathgate, M. Brokenshire, L. Latorre, E. Velemu, C. Carlos, S. Leano, E. O. Telan, S. S. Goh, S. T. Koh, C. Ngan, A. L. Tan, S. Mananwatte, N. Piyanoot, S. Lokpichat, P. Sirivongranson, M. Fakahau, H. Sitanilei, Le Van Hung

Research output: Contribution to journalArticle

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Abstract

Long-term surveillance of antimicrobial resistance in Neisseria gonorrhoeae has been conducted in the World Health Organization (WHO) Western Pacific Region (WPR) to optimise antibiotic treatment of gonococcal disease since 1992. In 2007 and 2008, this Gonococcal Antimicrobial Surveillance Programme (GASP) was enhanced by the inclusion of data from the South East Asian Region (SEAR) and recruitment of additional centres within the WPR. Approximately 17,450 N. gonorrhoeae were examined for their susceptibility to one or more antibiotics used for the treatment of gonorrhoea by external quality controlled methods in 24 reporting centres in 20 countries and/or jurisdictions. A high proportion of penicillin and/or quinolone resistance was again detected amongst isolates tested in North Asia and the WHO SEAR, but much lower rates of penicillin resistance and little quinolone resistance was present in most of the Pacific Island countries. The proportion of gonococci reported as 'resistant', 'less susceptible' or 'non-susceptible' gonococci to the third-generation cephalosporin antibiotic ceftriaxone lay in a wide range, but no major changes were evident in cephalosporin minimal inhibitory concentration (MIC) patterns in 2007-2008. Altered cephalosporin susceptibility was associated with treatment failures following therapy with oral third-generation cephalosporins. There is a need for revision and clarification of some of the in vitro criteria that are currently used to categorise the clinical importance of gonococci with different ceftriaxone and oral cephalosporin MIC levels. The number of instances of spectinomycin resistance remained low. A high proportion of strains tested continued to exhibit a form of plasmid mediated high level resistance to tetracyclines. The continuing emergence and spread of antibiotic resistant gonococci in and from the WHO WPR and SEAR supports the need for gonococcal antimicrobial resistance surveillance programs such as GASP to be maintained and potentially expanded.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalCommunicable diseases intelligence
Volume34
Issue number1
Publication statusPublished - 2010 Mar 1

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Neisseria gonorrhoeae
Microbial Drug Resistance
Cephalosporins
Ceftriaxone
Quinolones
Anti-Bacterial Agents
Northern Asia
Pacific Islands
Spectinomycin
Penicillin Resistance
Tetracycline Resistance
Gonorrhea
Treatment Failure
Penicillins
Plasmids
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

WHO Western Pacific Programme, W. P. P., South East Asian Gonococcal Antimicrobial Surveillance Programme, E. A. G. A. S. P., Tapsall, J. W., Limnios, E. A., Abu Bakar, H. M. H., Darussalam, B., ... Hung, L. V. (2010). Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian regions, 2007-2008. Communicable diseases intelligence, 34(1), 1-7.
WHO Western Pacific Programme, Western Pacific Programme ; South East Asian Gonococcal Antimicrobial Surveillance Programme, East Asian Gonococcal Antimicrobial Surveillance Programme ; Tapsall, J. W. ; Limnios, E. A. ; Abu Bakar, Hjh Mahani Hj ; Darussalam, Brunei ; Ping, Yin Yue ; Buadromo, E. M. ; Kumar, P. ; Singh, S. ; Lo, J. ; Bala, M. ; Risbud, A. ; Deguchi, T. ; Tanaka, M. ; Watanabe, Y. ; Lee, Kyungwon ; Chong, Y. ; Noikaseumsy, S. ; Phouthavane, T. ; Sam, I. Ching ; Tundev, O. ; Lwin, K. M. ; Eh, P. H. ; Goorant, C. ; Goursaud, R. ; Bathgate, T. ; Brokenshire, M. ; Latorre, L. ; Velemu, E. ; Carlos, C. ; Leano, S. ; Telan, E. O. ; Goh, S. S. ; Koh, S. T. ; Ngan, C. ; Tan, A. L. ; Mananwatte, S. ; Piyanoot, N. ; Lokpichat, S. ; Sirivongranson, P. ; Fakahau, M. ; Sitanilei, H. ; Hung, Le Van. / Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian regions, 2007-2008. In: Communicable diseases intelligence. 2010 ; Vol. 34, No. 1. pp. 1-7.
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abstract = "Long-term surveillance of antimicrobial resistance in Neisseria gonorrhoeae has been conducted in the World Health Organization (WHO) Western Pacific Region (WPR) to optimise antibiotic treatment of gonococcal disease since 1992. In 2007 and 2008, this Gonococcal Antimicrobial Surveillance Programme (GASP) was enhanced by the inclusion of data from the South East Asian Region (SEAR) and recruitment of additional centres within the WPR. Approximately 17,450 N. gonorrhoeae were examined for their susceptibility to one or more antibiotics used for the treatment of gonorrhoea by external quality controlled methods in 24 reporting centres in 20 countries and/or jurisdictions. A high proportion of penicillin and/or quinolone resistance was again detected amongst isolates tested in North Asia and the WHO SEAR, but much lower rates of penicillin resistance and little quinolone resistance was present in most of the Pacific Island countries. The proportion of gonococci reported as 'resistant', 'less susceptible' or 'non-susceptible' gonococci to the third-generation cephalosporin antibiotic ceftriaxone lay in a wide range, but no major changes were evident in cephalosporin minimal inhibitory concentration (MIC) patterns in 2007-2008. Altered cephalosporin susceptibility was associated with treatment failures following therapy with oral third-generation cephalosporins. There is a need for revision and clarification of some of the in vitro criteria that are currently used to categorise the clinical importance of gonococci with different ceftriaxone and oral cephalosporin MIC levels. The number of instances of spectinomycin resistance remained low. A high proportion of strains tested continued to exhibit a form of plasmid mediated high level resistance to tetracyclines. The continuing emergence and spread of antibiotic resistant gonococci in and from the WHO WPR and SEAR supports the need for gonococcal antimicrobial resistance surveillance programs such as GASP to be maintained and potentially expanded.",
author = "{WHO Western Pacific Programme}, {Western Pacific Programme} and {South East Asian Gonococcal Antimicrobial Surveillance Programme}, {East Asian Gonococcal Antimicrobial Surveillance Programme} and Tapsall, {J. W.} and Limnios, {E. A.} and {Abu Bakar}, {Hjh Mahani Hj} and Brunei Darussalam and Ping, {Yin Yue} and Buadromo, {E. M.} and P. Kumar and S. Singh and J. Lo and M. Bala and A. Risbud and T. Deguchi and M. Tanaka and Y. Watanabe and Kyungwon Lee and Y. Chong and S. Noikaseumsy and T. Phouthavane and Sam, {I. Ching} and O. Tundev and Lwin, {K. M.} and Eh, {P. H.} and C. Goorant and R. Goursaud and T. Bathgate and M. Brokenshire and L. Latorre and E. Velemu and C. Carlos and S. Leano and Telan, {E. O.} and Goh, {S. S.} and Koh, {S. T.} and C. Ngan and Tan, {A. L.} and S. Mananwatte and N. Piyanoot and S. Lokpichat and P. Sirivongranson and M. Fakahau and H. Sitanilei and Hung, {Le Van}",
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WHO Western Pacific Programme, WPP, South East Asian Gonococcal Antimicrobial Surveillance Programme, EAGASP, Tapsall, JW, Limnios, EA, Abu Bakar, HMH, Darussalam, B, Ping, YY, Buadromo, EM, Kumar, P, Singh, S, Lo, J, Bala, M, Risbud, A, Deguchi, T, Tanaka, M, Watanabe, Y, Lee, K, Chong, Y, Noikaseumsy, S, Phouthavane, T, Sam, IC, Tundev, O, Lwin, KM, Eh, PH, Goorant, C, Goursaud, R, Bathgate, T, Brokenshire, M, Latorre, L, Velemu, E, Carlos, C, Leano, S, Telan, EO, Goh, SS, Koh, ST, Ngan, C, Tan, AL, Mananwatte, S, Piyanoot, N, Lokpichat, S, Sirivongranson, P, Fakahau, M, Sitanilei, H & Hung, LV 2010, 'Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian regions, 2007-2008.', Communicable diseases intelligence, vol. 34, no. 1, pp. 1-7.

Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian regions, 2007-2008. / WHO Western Pacific Programme, Western Pacific Programme; South East Asian Gonococcal Antimicrobial Surveillance Programme, East Asian Gonococcal Antimicrobial Surveillance Programme; Tapsall, J. W.; Limnios, E. A.; Abu Bakar, Hjh Mahani Hj; Darussalam, Brunei; Ping, Yin Yue; Buadromo, E. M.; Kumar, P.; Singh, S.; Lo, J.; Bala, M.; Risbud, A.; Deguchi, T.; Tanaka, M.; Watanabe, Y.; Lee, Kyungwon; Chong, Y.; Noikaseumsy, S.; Phouthavane, T.; Sam, I. Ching; Tundev, O.; Lwin, K. M.; Eh, P. H.; Goorant, C.; Goursaud, R.; Bathgate, T.; Brokenshire, M.; Latorre, L.; Velemu, E.; Carlos, C.; Leano, S.; Telan, E. O.; Goh, S. S.; Koh, S. T.; Ngan, C.; Tan, A. L.; Mananwatte, S.; Piyanoot, N.; Lokpichat, S.; Sirivongranson, P.; Fakahau, M.; Sitanilei, H.; Hung, Le Van.

In: Communicable diseases intelligence, Vol. 34, No. 1, 01.03.2010, p. 1-7.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian regions, 2007-2008.

AU - WHO Western Pacific Programme, Western Pacific Programme

AU - South East Asian Gonococcal Antimicrobial Surveillance Programme, East Asian Gonococcal Antimicrobial Surveillance Programme

AU - Tapsall, J. W.

AU - Limnios, E. A.

AU - Abu Bakar, Hjh Mahani Hj

AU - Darussalam, Brunei

AU - Ping, Yin Yue

AU - Buadromo, E. M.

AU - Kumar, P.

AU - Singh, S.

AU - Lo, J.

AU - Bala, M.

AU - Risbud, A.

AU - Deguchi, T.

AU - Tanaka, M.

AU - Watanabe, Y.

AU - Lee, Kyungwon

AU - Chong, Y.

AU - Noikaseumsy, S.

AU - Phouthavane, T.

AU - Sam, I. Ching

AU - Tundev, O.

AU - Lwin, K. M.

AU - Eh, P. H.

AU - Goorant, C.

AU - Goursaud, R.

AU - Bathgate, T.

AU - Brokenshire, M.

AU - Latorre, L.

AU - Velemu, E.

AU - Carlos, C.

AU - Leano, S.

AU - Telan, E. O.

AU - Goh, S. S.

AU - Koh, S. T.

AU - Ngan, C.

AU - Tan, A. L.

AU - Mananwatte, S.

AU - Piyanoot, N.

AU - Lokpichat, S.

AU - Sirivongranson, P.

AU - Fakahau, M.

AU - Sitanilei, H.

AU - Hung, Le Van

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Long-term surveillance of antimicrobial resistance in Neisseria gonorrhoeae has been conducted in the World Health Organization (WHO) Western Pacific Region (WPR) to optimise antibiotic treatment of gonococcal disease since 1992. In 2007 and 2008, this Gonococcal Antimicrobial Surveillance Programme (GASP) was enhanced by the inclusion of data from the South East Asian Region (SEAR) and recruitment of additional centres within the WPR. Approximately 17,450 N. gonorrhoeae were examined for their susceptibility to one or more antibiotics used for the treatment of gonorrhoea by external quality controlled methods in 24 reporting centres in 20 countries and/or jurisdictions. A high proportion of penicillin and/or quinolone resistance was again detected amongst isolates tested in North Asia and the WHO SEAR, but much lower rates of penicillin resistance and little quinolone resistance was present in most of the Pacific Island countries. The proportion of gonococci reported as 'resistant', 'less susceptible' or 'non-susceptible' gonococci to the third-generation cephalosporin antibiotic ceftriaxone lay in a wide range, but no major changes were evident in cephalosporin minimal inhibitory concentration (MIC) patterns in 2007-2008. Altered cephalosporin susceptibility was associated with treatment failures following therapy with oral third-generation cephalosporins. There is a need for revision and clarification of some of the in vitro criteria that are currently used to categorise the clinical importance of gonococci with different ceftriaxone and oral cephalosporin MIC levels. The number of instances of spectinomycin resistance remained low. A high proportion of strains tested continued to exhibit a form of plasmid mediated high level resistance to tetracyclines. The continuing emergence and spread of antibiotic resistant gonococci in and from the WHO WPR and SEAR supports the need for gonococcal antimicrobial resistance surveillance programs such as GASP to be maintained and potentially expanded.

AB - Long-term surveillance of antimicrobial resistance in Neisseria gonorrhoeae has been conducted in the World Health Organization (WHO) Western Pacific Region (WPR) to optimise antibiotic treatment of gonococcal disease since 1992. In 2007 and 2008, this Gonococcal Antimicrobial Surveillance Programme (GASP) was enhanced by the inclusion of data from the South East Asian Region (SEAR) and recruitment of additional centres within the WPR. Approximately 17,450 N. gonorrhoeae were examined for their susceptibility to one or more antibiotics used for the treatment of gonorrhoea by external quality controlled methods in 24 reporting centres in 20 countries and/or jurisdictions. A high proportion of penicillin and/or quinolone resistance was again detected amongst isolates tested in North Asia and the WHO SEAR, but much lower rates of penicillin resistance and little quinolone resistance was present in most of the Pacific Island countries. The proportion of gonococci reported as 'resistant', 'less susceptible' or 'non-susceptible' gonococci to the third-generation cephalosporin antibiotic ceftriaxone lay in a wide range, but no major changes were evident in cephalosporin minimal inhibitory concentration (MIC) patterns in 2007-2008. Altered cephalosporin susceptibility was associated with treatment failures following therapy with oral third-generation cephalosporins. There is a need for revision and clarification of some of the in vitro criteria that are currently used to categorise the clinical importance of gonococci with different ceftriaxone and oral cephalosporin MIC levels. The number of instances of spectinomycin resistance remained low. A high proportion of strains tested continued to exhibit a form of plasmid mediated high level resistance to tetracyclines. The continuing emergence and spread of antibiotic resistant gonococci in and from the WHO WPR and SEAR supports the need for gonococcal antimicrobial resistance surveillance programs such as GASP to be maintained and potentially expanded.

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WHO Western Pacific Programme WPP, South East Asian Gonococcal Antimicrobial Surveillance Programme EAGASP, Tapsall JW, Limnios EA, Abu Bakar HMH, Darussalam B et al. Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian regions, 2007-2008. Communicable diseases intelligence. 2010 Mar 1;34(1):1-7.