Surveillance strategy for rectal neuroendocrine tumors according to recurrence risk stratification

Dong Hyun Kim, Jin Ha Lee, Yoon Jin Cha, Soo Jung Park, Jae Hee Cheon, Tae Il Kim, Hoguen Kim, Won Ho Kim, Sung Pil Hong

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background/Aim: Rectal neuroendocrine tumors (NETs) have been increasing in incidence. However, the recommendations for disease surveillance after tumor resection have not been well established. We evaluated the long-term outcomes of rectal NETs and surveillance strategies according to recurrence risk stratification. Methods: From January 2000 to July 2011, 188 patients diagnosed with rectal NETs were included in this study. Patient characteristics, treatment methods, recurrence rates, risk factors of recurrence, and surveillance schedules were analyzed. Results: The male-to-female ratio was 1.29:1 and the mean age at diagnosis was 50.6 years. The mean tumor size was 6.5 (range 1-30) mm. A total of 144 patients (76.6 %) were treated with endoscopic resection, and 44 patients (23.4 %) were treated with surgical resection as the initial treatment. During the follow-up period, ten patients (5.3 %) had disease recurrence, including one case of local recurrence and nine cases of recurrence at a distant site. Tumor size of >10 mm, invasion of the muscularis propria, increased mitotic index, lymphovascular invasion, and regional lymph node metastases were statistically significant predictors of recurrence by univariate analysis. Among the 152 patients without risk factors of recurrence, only one patient who underwent transanal resection had a local recurrence at 15 months after surgery. Conclusion: Our patients with rectal NETs showed favorable clinical outcomes and had a low rate of recurrence. Intensive surveillance with endoscopy or imaging study may not be required in patients without risk factors for recurrence.

Original languageEnglish
Pages (from-to)850-856
Number of pages7
JournalDigestive diseases and sciences
Volume59
Issue number4
DOIs
Publication statusPublished - 2014 Apr

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Neuroendocrine Tumors
Rectal Neoplasms
Recurrence
Neoplasms
Mitotic Index
Endoscopy
Appointments and Schedules
Lymph Nodes
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Kim, Dong Hyun ; Lee, Jin Ha ; Cha, Yoon Jin ; Park, Soo Jung ; Cheon, Jae Hee ; Kim, Tae Il ; Kim, Hoguen ; Kim, Won Ho ; Hong, Sung Pil. / Surveillance strategy for rectal neuroendocrine tumors according to recurrence risk stratification. In: Digestive diseases and sciences. 2014 ; Vol. 59, No. 4. pp. 850-856.
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abstract = "Background/Aim: Rectal neuroendocrine tumors (NETs) have been increasing in incidence. However, the recommendations for disease surveillance after tumor resection have not been well established. We evaluated the long-term outcomes of rectal NETs and surveillance strategies according to recurrence risk stratification. Methods: From January 2000 to July 2011, 188 patients diagnosed with rectal NETs were included in this study. Patient characteristics, treatment methods, recurrence rates, risk factors of recurrence, and surveillance schedules were analyzed. Results: The male-to-female ratio was 1.29:1 and the mean age at diagnosis was 50.6 years. The mean tumor size was 6.5 (range 1-30) mm. A total of 144 patients (76.6 {\%}) were treated with endoscopic resection, and 44 patients (23.4 {\%}) were treated with surgical resection as the initial treatment. During the follow-up period, ten patients (5.3 {\%}) had disease recurrence, including one case of local recurrence and nine cases of recurrence at a distant site. Tumor size of >10 mm, invasion of the muscularis propria, increased mitotic index, lymphovascular invasion, and regional lymph node metastases were statistically significant predictors of recurrence by univariate analysis. Among the 152 patients without risk factors of recurrence, only one patient who underwent transanal resection had a local recurrence at 15 months after surgery. Conclusion: Our patients with rectal NETs showed favorable clinical outcomes and had a low rate of recurrence. Intensive surveillance with endoscopy or imaging study may not be required in patients without risk factors for recurrence.",
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Surveillance strategy for rectal neuroendocrine tumors according to recurrence risk stratification. / Kim, Dong Hyun; Lee, Jin Ha; Cha, Yoon Jin; Park, Soo Jung; Cheon, Jae Hee; Kim, Tae Il; Kim, Hoguen; Kim, Won Ho; Hong, Sung Pil.

In: Digestive diseases and sciences, Vol. 59, No. 4, 04.2014, p. 850-856.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Surveillance strategy for rectal neuroendocrine tumors according to recurrence risk stratification

AU - Kim, Dong Hyun

AU - Lee, Jin Ha

AU - Cha, Yoon Jin

AU - Park, Soo Jung

AU - Cheon, Jae Hee

AU - Kim, Tae Il

AU - Kim, Hoguen

AU - Kim, Won Ho

AU - Hong, Sung Pil

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N2 - Background/Aim: Rectal neuroendocrine tumors (NETs) have been increasing in incidence. However, the recommendations for disease surveillance after tumor resection have not been well established. We evaluated the long-term outcomes of rectal NETs and surveillance strategies according to recurrence risk stratification. Methods: From January 2000 to July 2011, 188 patients diagnosed with rectal NETs were included in this study. Patient characteristics, treatment methods, recurrence rates, risk factors of recurrence, and surveillance schedules were analyzed. Results: The male-to-female ratio was 1.29:1 and the mean age at diagnosis was 50.6 years. The mean tumor size was 6.5 (range 1-30) mm. A total of 144 patients (76.6 %) were treated with endoscopic resection, and 44 patients (23.4 %) were treated with surgical resection as the initial treatment. During the follow-up period, ten patients (5.3 %) had disease recurrence, including one case of local recurrence and nine cases of recurrence at a distant site. Tumor size of >10 mm, invasion of the muscularis propria, increased mitotic index, lymphovascular invasion, and regional lymph node metastases were statistically significant predictors of recurrence by univariate analysis. Among the 152 patients without risk factors of recurrence, only one patient who underwent transanal resection had a local recurrence at 15 months after surgery. Conclusion: Our patients with rectal NETs showed favorable clinical outcomes and had a low rate of recurrence. Intensive surveillance with endoscopy or imaging study may not be required in patients without risk factors for recurrence.

AB - Background/Aim: Rectal neuroendocrine tumors (NETs) have been increasing in incidence. However, the recommendations for disease surveillance after tumor resection have not been well established. We evaluated the long-term outcomes of rectal NETs and surveillance strategies according to recurrence risk stratification. Methods: From January 2000 to July 2011, 188 patients diagnosed with rectal NETs were included in this study. Patient characteristics, treatment methods, recurrence rates, risk factors of recurrence, and surveillance schedules were analyzed. Results: The male-to-female ratio was 1.29:1 and the mean age at diagnosis was 50.6 years. The mean tumor size was 6.5 (range 1-30) mm. A total of 144 patients (76.6 %) were treated with endoscopic resection, and 44 patients (23.4 %) were treated with surgical resection as the initial treatment. During the follow-up period, ten patients (5.3 %) had disease recurrence, including one case of local recurrence and nine cases of recurrence at a distant site. Tumor size of >10 mm, invasion of the muscularis propria, increased mitotic index, lymphovascular invasion, and regional lymph node metastases were statistically significant predictors of recurrence by univariate analysis. Among the 152 patients without risk factors of recurrence, only one patient who underwent transanal resection had a local recurrence at 15 months after surgery. Conclusion: Our patients with rectal NETs showed favorable clinical outcomes and had a low rate of recurrence. Intensive surveillance with endoscopy or imaging study may not be required in patients without risk factors for recurrence.

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