Swarming Magnetic Photoactive Microrobots for Dental Implant Biofilm Eradication

Carmen C. Mayorga-Martinez, Jaroslav Zelenka, Karel Klima, Paula Mayorga-Burrezo, Lan Hoang, Tomas Ruml, Martin Pumera

Research output: Contribution to journalArticlepeer-review

Abstract

Titanium dental implants are a multibillion dollar market in the United States alone. The growth of a bacterial biofilm on a dental implant can cause gingivitis, implant loss, and expensive subsequent care. Herein, we demonstrate the efficient eradication of dental biofilm on titanium dental implants via swarming magnetic microrobots based on ferromagnetic (Fe3O4) and photoactive (BiVO4) materials through polyethylenimine micelles. The ferromagnetic component serves as a propulsion force using a transversal rotating magnetic field while BiVO4is the photoactive generator of reactive oxygen species to eradicate the biofilm colonies. Such photoactive magnetically powered, precisely navigated microrobots are able to destroy biofilm colonies on titanium implants, demonstrating their use in precision medicine.

Original languageEnglish
Pages (from-to)8694-8703
Number of pages10
JournalACS Nano
Volume16
Issue number6
DOIs
Publication statusPublished - 2022 Jun 28

Bibliographical note

Funding Information:
This work was supported by the project “Advanced Functional Nanorobots” (reg. no. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR), the Ministry of Health of the Czech Republic (NU21-08-00407), and Ministry of Education, Youth and Sports (Czech Republic) grant LL2002 under ERC CZ program. We thank MIS (MIS Implants Technologies Ltd., Israel) for donating dental implants. We did not receive any other support from MIS.

Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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