Syndrome of inappropriate antidiuretic hormone secretion in a patient with large cell neuroendocrine carcinoma

Hyung Jung Oh, Mi Jung Lee, Seon Jung Jang, Dong Ho Shin, Shin Wook Kang

Research output: Contribution to journalArticle

Abstract

The syndrome of inappropriate antidiuretic hormone secretion has only been reported in a few patients with large cell neuroendocrine carcinoma (LCNEC); however, it has never been reported in a patient with LCNEC of the lung, whose serum sodium levels were normalized after surgical resection of the mass. A 63-year-old male presented with a two-day history of dizziness and recent memory loss. On admission, his serum sodium level was 113 mEq/L with a serum osmolality of 236 mosm/kg, a urine osmolality of 441 mosm/kg, and a urine sodium level of 65 mEq/L. His chest computed tomography revealed a 2.7×2.3 cm-sized mass in the left lower lobe. After surgical removal of the mass, his serum sodium concentrations were normalized, and histopathology of the mass revealed LCNEC.

Original languageEnglish
Pages (from-to)667-669
Number of pages3
JournalYonsei medical journal
Volume53
Issue number3
DOIs
Publication statusPublished - 2012 May 1

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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