Abstract
The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C.
Original language | English |
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Pages (from-to) | 1098-1101 |
Number of pages | 4 |
Journal | Clinical Microbiology and Infection |
Volume | 10 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2004 Dec |
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases