Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii

J. Y. Choi; Y. Soo Park; C. H. Cho; Y. Seon Park; S. Y. Shin; Y. G. Song; D. Yong; K. Lee; J. M. Kim

doi:10.1111/j.1469-0691.2004.00987.x

Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii

J. Y. Choi, Y. Soo Park, C. H. Cho, Y. Seon Park, S. Y. Shin, Y. G. Song, D. Yong, K. Lee, J. M. Kim

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C.

Original language	English
Pages (from-to)	1098-1101
Number of pages	4
Journal	Clinical Microbiology and Infection
Volume	10
Issue number	12
DOIs	https://doi.org/10.1111/j.1469-0691.2004.00987.x
Publication status	Published - 2004 Dec

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

Access to Document

10.1111/j.1469-0691.2004.00987.x

Cite this

@article{a6ed833a0d6b4ab28f5c9fa00f1fb444,

title = "Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii",

abstract = "The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C.",

author = "Choi, {J. Y.} and {Soo Park}, Y. and Cho, {C. H.} and {Seon Park}, Y. and Shin, {S. Y.} and Song, {Y. G.} and D. Yong and K. Lee and Kim, {J. M.}",

year = "2004",

month = dec,

doi = "10.1111/j.1469-0691.2004.00987.x",

language = "English",

volume = "10",

pages = "1098--1101",

journal = "Clinical Microbiology and Infection",

issn = "1198-743X",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii

AU - Choi, J. Y.

AU - Soo Park, Y.

AU - Cho, C. H.

AU - Seon Park, Y.

AU - Shin, S. Y.

AU - Song, Y. G.

AU - Yong, D.

AU - Lee, K.

AU - Kim, J. M.

PY - 2004/12

Y1 - 2004/12

N2 - The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C.

AB - The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C.

UR - http://www.scopus.com/inward/record.url?scp=11044227695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11044227695&partnerID=8YFLogxK

U2 - 10.1111/j.1469-0691.2004.00987.x

DO - 10.1111/j.1469-0691.2004.00987.x

M3 - Article

C2 - 15606639

AN - SCOPUS:11044227695

VL - 10

SP - 1098

EP - 1101

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 12

ER -

Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this