Abstract
The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C.
| Original language | English |
|---|---|
| Pages (from-to) | 1098-1101 |
| Number of pages | 4 |
| Journal | Clinical Microbiology and Infection |
| Volume | 10 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2004 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases
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Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii. / Choi, JunYong; Soo Park, Y.; Cho, C. H.; Seon Park, Y.; Shin, S. Y.; Song, Y. G.; Yong, DongEun; Lee, Kyungwon; Kim, J. M.
In: Clinical Microbiology and Infection, Vol. 10, No. 12, 01.01.2004, p. 1098-1101.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii
AU - Choi, JunYong
AU - Soo Park, Y.
AU - Cho, C. H.
AU - Seon Park, Y.
AU - Shin, S. Y.
AU - Song, Y. G.
AU - Yong, DongEun
AU - Lee, Kyungwon
AU - Kim, J. M.
PY - 2004/1/1
Y1 - 2004/1/1
N2 - The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C.
AB - The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C.
UR - http://www.scopus.com/inward/record.url?scp=11044227695&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11044227695&partnerID=8YFLogxK
U2 - 10.1111/j.1469-0691.2004.00987.x
DO - 10.1111/j.1469-0691.2004.00987.x
M3 - Article
C2 - 15606639
AN - SCOPUS:11044227695
VL - 10
SP - 1098
EP - 1101
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
SN - 1198-743X
IS - 12
ER -