Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii

J. Y. Choi, Y. Soo Park, C. H. Cho, Y. Seon Park, S. Y. Shin, Y. G. Song, D. Yong, K. Lee, J. M. Kim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C.

Original languageEnglish
Pages (from-to)1098-1101
Number of pages4
JournalClinical Microbiology and Infection
Volume10
Issue number12
DOIs
Publication statusPublished - 2004 Dec

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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