Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii

J. Y. Choi; Y. Soo Park; C. H. Cho; Y. Seon Park; S. Y. Shin; Y. G. Song; D. Yong; K. Lee; J. M. Kim

doi:10.1111/j.1469-0691.2004.00987.x

Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii

J. Y. Choi, Y. Soo Park, C. H. Cho, Y. Seon Park, S. Y. Shin, Y. G. Song, D. Yong, K. Lee, J. M. Kim

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C.

Original language	English
Pages (from-to)	1098-1101
Number of pages	4
Journal	Clinical Microbiology and Infection
Volume	10
Issue number	12
DOIs	https://doi.org/10.1111/j.1469-0691.2004.00987.x
Publication status	Published - 2004 Dec

Bibliographical note

Funding Information:
This study was supported by the BK21 Project for Medical Sciences, Yonsei University.

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

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title = "Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii",

abstract = "The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C.",

author = "Choi, {J. Y.} and {Soo Park}, Y. and Cho, {C. H.} and {Seon Park}, Y. and Shin, {S. Y.} and Song, {Y. G.} and D. Yong and K. Lee and Kim, {J. M.}",

note = "Funding Information: This study was supported by the BK21 Project for Medical Sciences, Yonsei University.",

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AU - Choi, J. Y.

AU - Soo Park, Y.

AU - Cho, C. H.

AU - Seon Park, Y.

AU - Shin, S. Y.

AU - Song, Y. G.

AU - Yong, D.

AU - Lee, K.

AU - Kim, J. M.

N1 - Funding Information: This study was supported by the BK21 Project for Medical Sciences, Yonsei University.

PY - 2004/12

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