Synergistic effect of 300 µm needle-depth fractional microneedling radiofrequency on the treatment of senescence-induced aging hyperpigmentation of the skin

Young In Lee; Eunbin Kim; Dong Won Lee; Jemin Kim; Jihee Kim; Won Jai Lee; Ju Hee Lee

doi:10.3390/ijms22147480

Synergistic effect of 300 µm needle-depth fractional microneedling radiofrequency on the treatment of senescence-induced aging hyperpigmentation of the skin

Young In Lee, Eunbin Kim, Dong Won Lee, Jemin Kim, Jihee Kim, Won Jai Lee, Ju Hee Lee

Department of Dermatology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Aging-associated dermatological pigmentary diseases are associated with accumulation of senescence cells and the disruption of basement membrane due to chronic ultraviolet radiation (UVR) exposure. Our study is on the synergistic effect of the novel 300 µm needle-depth fractional microneedling radiofrequency (FMR) treatment and conventional Q-switched ND:YAG laser on aging-associated hyperpigmentation of the skin. The prospective controlled clinical trial of 25 Asian women revealed significantly higher improvements not only on wrinkles, but also on hyperpigmentation. Additional ex vivo study revealed significant reduction of pro-melanogenic markers as well as senescent keratinocytes, while increased expression of collagen type IV on the epidermal basement membrane, after additional FMR treatment on UV-irradiated human tissues. These results demonstrate that 300 µm needle-depth FMR might effectively remove senescent keratinocytes that secrete pro-melanogenic markers, and repair disrupted basement membrane, therefore preventing constant hyperpigmentation of the aged skin.

Original language	English
Article number	7480
Journal	International journal of molecular sciences
Volume	22
Issue number	14
DOIs	https://doi.org/10.3390/ijms22147480
Publication status	Published - 2021 Jul 2

Bibliographical note

Funding Information:
Funding: This work was also supported by the grant of the Korea Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HP20C0171) and by the Yonsei University Faculty Research Grant (6-2020-0081). The research was also supported by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, Republic of Korea, the Ministry of Food and Drug Safety) (Project Number: 202014X4502).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Synergistic effect of 300 µm needle-depth fractional microneedling radiofrequency on the treatment of senescence-induced aging hyperpigmentation of the skin",

abstract = "Aging-associated dermatological pigmentary diseases are associated with accumulation of senescence cells and the disruption of basement membrane due to chronic ultraviolet radiation (UVR) exposure. Our study is on the synergistic effect of the novel 300 µm needle-depth fractional microneedling radiofrequency (FMR) treatment and conventional Q-switched ND:YAG laser on aging-associated hyperpigmentation of the skin. The prospective controlled clinical trial of 25 Asian women revealed significantly higher improvements not only on wrinkles, but also on hyperpigmentation. Additional ex vivo study revealed significant reduction of pro-melanogenic markers as well as senescent keratinocytes, while increased expression of collagen type IV on the epidermal basement membrane, after additional FMR treatment on UV-irradiated human tissues. These results demonstrate that 300 µm needle-depth FMR might effectively remove senescent keratinocytes that secrete pro-melanogenic markers, and repair disrupted basement membrane, therefore preventing constant hyperpigmentation of the aged skin.",

author = "Lee, {Young In} and Eunbin Kim and Lee, {Dong Won} and Jemin Kim and Jihee Kim and Lee, {Won Jai} and Lee, {Ju Hee}",

note = "Funding Information: Funding: This work was also supported by the grant of the Korea Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HP20C0171) and by the Yonsei University Faculty Research Grant (6-2020-0081). The research was also supported by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, Republic of Korea, the Ministry of Food and Drug Safety) (Project Number: 202014X4502). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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N2 - Aging-associated dermatological pigmentary diseases are associated with accumulation of senescence cells and the disruption of basement membrane due to chronic ultraviolet radiation (UVR) exposure. Our study is on the synergistic effect of the novel 300 µm needle-depth fractional microneedling radiofrequency (FMR) treatment and conventional Q-switched ND:YAG laser on aging-associated hyperpigmentation of the skin. The prospective controlled clinical trial of 25 Asian women revealed significantly higher improvements not only on wrinkles, but also on hyperpigmentation. Additional ex vivo study revealed significant reduction of pro-melanogenic markers as well as senescent keratinocytes, while increased expression of collagen type IV on the epidermal basement membrane, after additional FMR treatment on UV-irradiated human tissues. These results demonstrate that 300 µm needle-depth FMR might effectively remove senescent keratinocytes that secrete pro-melanogenic markers, and repair disrupted basement membrane, therefore preventing constant hyperpigmentation of the aged skin.

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Synergistic effect of 300 µm needle-depth fractional microneedling radiofrequency on the treatment of senescence-induced aging hyperpigmentation of the skin

Abstract

Bibliographical note

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UN SDGs

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