Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome

Mizuho Hiramatsu, Mitsutoshi Oguri, Kimihiko Kato, Hideki Horibe, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Dong Jik Shin, Jong Ho Lee, Yangsoo Jang, Yoshiji Yamada

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Abstract

We previously showed that the -1131T→C polymorphism (rs662799) of the apolipoprotein A-V gene (APOA5) and the C.T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) were significantly associated with an increased serum concentration of triglycerides, a decreased serum concentration of high density lipoprotein (HDL)-cholesterol, and the prevalence of metabolic syndrome (MetS) in Japanese individuals. The purpose of the present study was to examine whether these polymorphisms synergistically affect the prevalence of dyslipidemia and MetS in East Asian populations. The study populations comprised 7471 Japanese and 3529 Korean individuals in the dyslipidemia study, and 3474 Japanese and 1671 Korean individuals in the MetS study. Multivariable logistic regression analysis of combined genotypes with adjustment for age, gender and diabetes mellitus revealed that rs662799 and rs6929846 significantly and synergistically affected dyslipidemia. Japanese or Korean individuals with the C allele of APOA5 and the T allele of BTN2A1 had a 2.05- or 1.92-fold increased risk for hypertriglyceridemia and a 1.82- or 1.56-fold increased risk for hypo-HDL-cholesterolemia, respectively, compared to those with the TT genotype of APOA5 and the CC genotype of BTN2A1. Similar analysis with adjustment for age and gender revealed that Japanese individuals, but not Korean individuals, with the C allele of APOA5 and the T allele of BTN2A1 had a 2.87-fold increased risk for MetS compared to those with the TT genotype of APOA5 and the CC genotype of BTN2A1. Genetic variants of APOA5 and BTN2A1 may synergistically affect the prevalence of dyslipidemia in East Asian populations and of MetS in Japanese individuals.

Original languageEnglish
Pages (from-to)185-192
Number of pages8
JournalInternational journal of molecular medicine
Volume30
Issue number1
DOIs
Publication statusPublished - 2012 Jul 1

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Dyslipidemias
Genotype
Alleles
Population
Hypertriglyceridemia
HDL Lipoproteins
Serum
HDL Cholesterol
Genes
Diabetes Mellitus
Triglycerides
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Hiramatsu, M., Oguri, M., Kato, K., Horibe, H., Fujimaki, T., Watanabe, S., ... Yamada, Y. (2012). Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome. International journal of molecular medicine, 30(1), 185-192. https://doi.org/10.3892/ijmm.2012.976
Hiramatsu, Mizuho ; Oguri, Mitsutoshi ; Kato, Kimihiko ; Horibe, Hideki ; Fujimaki, Tetsuo ; Watanabe, Sachiro ; Satoh, Kei ; Aoyagi, Yukitoshi ; Tanaka, Masashi ; Shin, Dong Jik ; Lee, Jong Ho ; Jang, Yangsoo ; Yamada, Yoshiji. / Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome. In: International journal of molecular medicine. 2012 ; Vol. 30, No. 1. pp. 185-192.
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abstract = "We previously showed that the -1131T→C polymorphism (rs662799) of the apolipoprotein A-V gene (APOA5) and the C.T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) were significantly associated with an increased serum concentration of triglycerides, a decreased serum concentration of high density lipoprotein (HDL)-cholesterol, and the prevalence of metabolic syndrome (MetS) in Japanese individuals. The purpose of the present study was to examine whether these polymorphisms synergistically affect the prevalence of dyslipidemia and MetS in East Asian populations. The study populations comprised 7471 Japanese and 3529 Korean individuals in the dyslipidemia study, and 3474 Japanese and 1671 Korean individuals in the MetS study. Multivariable logistic regression analysis of combined genotypes with adjustment for age, gender and diabetes mellitus revealed that rs662799 and rs6929846 significantly and synergistically affected dyslipidemia. Japanese or Korean individuals with the C allele of APOA5 and the T allele of BTN2A1 had a 2.05- or 1.92-fold increased risk for hypertriglyceridemia and a 1.82- or 1.56-fold increased risk for hypo-HDL-cholesterolemia, respectively, compared to those with the TT genotype of APOA5 and the CC genotype of BTN2A1. Similar analysis with adjustment for age and gender revealed that Japanese individuals, but not Korean individuals, with the C allele of APOA5 and the T allele of BTN2A1 had a 2.87-fold increased risk for MetS compared to those with the TT genotype of APOA5 and the CC genotype of BTN2A1. Genetic variants of APOA5 and BTN2A1 may synergistically affect the prevalence of dyslipidemia in East Asian populations and of MetS in Japanese individuals.",
author = "Mizuho Hiramatsu and Mitsutoshi Oguri and Kimihiko Kato and Hideki Horibe and Tetsuo Fujimaki and Sachiro Watanabe and Kei Satoh and Yukitoshi Aoyagi and Masashi Tanaka and Shin, {Dong Jik} and Lee, {Jong Ho} and Yangsoo Jang and Yoshiji Yamada",
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Hiramatsu, M, Oguri, M, Kato, K, Horibe, H, Fujimaki, T, Watanabe, S, Satoh, K, Aoyagi, Y, Tanaka, M, Shin, DJ, Lee, JH, Jang, Y & Yamada, Y 2012, 'Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome', International journal of molecular medicine, vol. 30, no. 1, pp. 185-192. https://doi.org/10.3892/ijmm.2012.976

Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome. / Hiramatsu, Mizuho; Oguri, Mitsutoshi; Kato, Kimihiko; Horibe, Hideki; Fujimaki, Tetsuo; Watanabe, Sachiro; Satoh, Kei; Aoyagi, Yukitoshi; Tanaka, Masashi; Shin, Dong Jik; Lee, Jong Ho; Jang, Yangsoo; Yamada, Yoshiji.

In: International journal of molecular medicine, Vol. 30, No. 1, 01.07.2012, p. 185-192.

Research output: Contribution to journalArticle

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T1 - Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome

AU - Hiramatsu, Mizuho

AU - Oguri, Mitsutoshi

AU - Kato, Kimihiko

AU - Horibe, Hideki

AU - Fujimaki, Tetsuo

AU - Watanabe, Sachiro

AU - Satoh, Kei

AU - Aoyagi, Yukitoshi

AU - Tanaka, Masashi

AU - Shin, Dong Jik

AU - Lee, Jong Ho

AU - Jang, Yangsoo

AU - Yamada, Yoshiji

PY - 2012/7/1

Y1 - 2012/7/1

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AB - We previously showed that the -1131T→C polymorphism (rs662799) of the apolipoprotein A-V gene (APOA5) and the C.T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) were significantly associated with an increased serum concentration of triglycerides, a decreased serum concentration of high density lipoprotein (HDL)-cholesterol, and the prevalence of metabolic syndrome (MetS) in Japanese individuals. The purpose of the present study was to examine whether these polymorphisms synergistically affect the prevalence of dyslipidemia and MetS in East Asian populations. The study populations comprised 7471 Japanese and 3529 Korean individuals in the dyslipidemia study, and 3474 Japanese and 1671 Korean individuals in the MetS study. Multivariable logistic regression analysis of combined genotypes with adjustment for age, gender and diabetes mellitus revealed that rs662799 and rs6929846 significantly and synergistically affected dyslipidemia. Japanese or Korean individuals with the C allele of APOA5 and the T allele of BTN2A1 had a 2.05- or 1.92-fold increased risk for hypertriglyceridemia and a 1.82- or 1.56-fold increased risk for hypo-HDL-cholesterolemia, respectively, compared to those with the TT genotype of APOA5 and the CC genotype of BTN2A1. Similar analysis with adjustment for age and gender revealed that Japanese individuals, but not Korean individuals, with the C allele of APOA5 and the T allele of BTN2A1 had a 2.87-fold increased risk for MetS compared to those with the TT genotype of APOA5 and the CC genotype of BTN2A1. Genetic variants of APOA5 and BTN2A1 may synergistically affect the prevalence of dyslipidemia in East Asian populations and of MetS in Japanese individuals.

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