Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents

Sun Young Jang, Young Hwan Ha, Seung Whan Ko, Wonku Lee, Jongkook Lee, Sunghoon Kim, Yong Woo Kim, Won Koo Lee, Hyun Joon Ha

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A series of 4-arylpiperazin-1-yl-3-phenyloxazolidin-2-one derivatives with diversification of the N-substituents such as methylene O-linked heterocycles, thioamide, dithiocarbamate, thiourea, and thiocarbamate were synthesized and evaluated as antibacterial agents. Their in vitro activities (MIC) were evaluated against MRSA and VRE resistant Gram-positive strains such as Staphylococcus and Enterococcus. Most of the compounds were more potent in vitro but less active in vivo than linezolid.

Original languageEnglish
Pages (from-to)3881-3883
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number15
DOIs
Publication statusPublished - 2004 Aug 2

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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