Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.
Bibliographical noteFunding Information:
This study was supported by a Grant of the Disease Oriented Translational Research (DOTR) Project ( A084166 ), the Ministry of Health & Welfare , Republic of Korea. N.P. and Y.L. received fellowships from the BK21 program of the Ministry of Education and Human Resources Development, the Republic of Korea.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry