Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin

Mankil Jung; Namsoo Park; Hyung In Moon; Yongnam Lee; Won Yoon Chung; Kwang Kyun Park

doi:10.1016/j.bmcl.2009.09.093

Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin

Mankil Jung, Namsoo Park, Hyung In Moon, Yongnam Lee, Won Yoon Chung, Kwang Kyun Park

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.

Original language	English
Pages (from-to)	6303-6306
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2009.09.093
Publication status	Published - 2009

Bibliographical note

Funding Information:
This study was supported by a Grant of the Disease Oriented Translational Research (DOTR) Project ( A084166 ), the Ministry of Health & Welfare , Republic of Korea. N.P. and Y.L. received fellowships from the BK21 program of the Ministry of Education and Human Resources Development, the Republic of Korea.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bmcl.2009.09.093

Cite this

@article{9fefa54488d64339a0ca53dad575841d,

title = "Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin",

abstract = "Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.",

author = "Mankil Jung and Namsoo Park and Moon, {Hyung In} and Yongnam Lee and Chung, {Won Yoon} and Park, {Kwang Kyun}",

note = "Funding Information: This study was supported by a Grant of the Disease Oriented Translational Research (DOTR) Project ( A084166 ), the Ministry of Health & Welfare , Republic of Korea. N.P. and Y.L. received fellowships from the BK21 program of the Ministry of Education and Human Resources Development, the Republic of Korea.",

year = "2009",

doi = "10.1016/j.bmcl.2009.09.093",

language = "English",

volume = "19",

pages = "6303--6306",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "22",

}

TY - JOUR

T1 - Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin

AU - Jung, Mankil

AU - Park, Namsoo

AU - Moon, Hyung In

AU - Lee, Yongnam

AU - Chung, Won Yoon

AU - Park, Kwang Kyun

N1 - Funding Information: This study was supported by a Grant of the Disease Oriented Translational Research (DOTR) Project ( A084166 ), the Ministry of Health & Welfare , Republic of Korea. N.P. and Y.L. received fellowships from the BK21 program of the Ministry of Education and Human Resources Development, the Republic of Korea.

PY - 2009

Y1 - 2009

N2 - Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.

AB - Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.

UR - http://www.scopus.com/inward/record.url?scp=71049195428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71049195428&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2009.09.093

DO - 10.1016/j.bmcl.2009.09.093

M3 - Article

C2 - 19819696

AN - SCOPUS:71049195428

SN - 0960-894X

VL - 19

SP - 6303

EP - 6306

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 22

ER -

Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this