Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin

Mankil Jung, Namsoo Park, Hyung In Moon, Yongnam Lee, Won Yoon Chung, Kwang Kyun Park

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.

Original languageEnglish
Pages (from-to)6303-6306
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number22
DOIs
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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