Synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids

Dongguk Min, Minkyu Kim, Jéŕemy Ricci, Sora Jung, Kirim Kim, Won Yoon Chung, Kwang Kyun Park, Mankil Jung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin- glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.

Original languageEnglish
Pages (from-to)446-453
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Volume62
Issue number5
DOIs
Publication statusPublished - 2014 May

Fingerprint

Glycolipids
Thermodynamic properties
Cisplatin
Cells
Molecules
Pharmaceutical Preparations
Cell Line
deoxoartemisinin
Neoplasms
artemisinine

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

Min, Dongguk ; Kim, Minkyu ; Ricci, Jéŕemy ; Jung, Sora ; Kim, Kirim ; Chung, Won Yoon ; Park, Kwang Kyun ; Jung, Mankil. / Synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids. In: Chemical and Pharmaceutical Bulletin. 2014 ; Vol. 62, No. 5. pp. 446-453.
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Synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids. / Min, Dongguk; Kim, Minkyu; Ricci, Jéŕemy; Jung, Sora; Kim, Kirim; Chung, Won Yoon; Park, Kwang Kyun; Jung, Mankil.

In: Chemical and Pharmaceutical Bulletin, Vol. 62, No. 5, 05.2014, p. 446-453.

Research output: Contribution to journalArticle

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AU - Jung, Mankil

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