Synthesis and biological activity of fungal metabolite, 4-hydroxy-3-(3′-methyl-2′-butenyl)-benzoic acid

Hye Jin Kim, Ho Jeong Kwon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

4-Hydroxy-3-(3′-methyl-2′-butenyl)-benzoic acid (HMBA) was previously isolated from Curvularia sp. KF119 as a cell-cycle inhibitor. However, the present study used a novel and practical synthetic method to prepare a large quantity of HMBA. The synthetic HMBA was found to inhibit the cell-cycle progression of HeLa cells with a comparable potency to the natural fungal metabolite. The inhibition of the cell-cycle progression by the synthetic HMBA involved both the activation of p21WAF1 and the inhibition of cyclin D1 expression in the cells. Consequently, this new synthetic procedure provides an easy and convenient way to produce or manipulate the original fungal metabolite.

Original languageEnglish
Pages (from-to)543-545
Number of pages3
JournalJournal of microbiology and biotechnology
Volume17
Issue number3
Publication statusPublished - 2007 Mar 1

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hexamethylene bisacetamide
Benzoic Acid
Cell Cycle
Cyclin D1
HeLa Cells

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

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abstract = "4-Hydroxy-3-(3′-methyl-2′-butenyl)-benzoic acid (HMBA) was previously isolated from Curvularia sp. KF119 as a cell-cycle inhibitor. However, the present study used a novel and practical synthetic method to prepare a large quantity of HMBA. The synthetic HMBA was found to inhibit the cell-cycle progression of HeLa cells with a comparable potency to the natural fungal metabolite. The inhibition of the cell-cycle progression by the synthetic HMBA involved both the activation of p21WAF1 and the inhibition of cyclin D1 expression in the cells. Consequently, this new synthetic procedure provides an easy and convenient way to produce or manipulate the original fungal metabolite.",
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Synthesis and biological activity of fungal metabolite, 4-hydroxy-3-(3′-methyl-2′-butenyl)-benzoic acid. / Kim, Hye Jin; Kwon, Ho Jeong.

In: Journal of microbiology and biotechnology, Vol. 17, No. 3, 01.03.2007, p. 543-545.

Research output: Contribution to journalArticle

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