Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues

Yun Bong Kim, Yong Hae Kim, Ju Youn Park, Soo-Ki Kim

Research output: Contribution to journalArticle

212 Citations (Scopus)

Abstract

Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound 1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 μg/mL. According to the eukaryotic or prokaryotic data, 1a might be a first analogue to replace echinomycin.

Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number2
DOIs
Publication statusPublished - 2004 Jan 1

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Echinomycin
Quinoxalines
Bioactivity
Anti-Bacterial Agents
Vancomycin
Cytotoxicity
Tumor Cell Line
Tumors
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues. / Kim, Yun Bong; Kim, Yong Hae; Park, Ju Youn; Kim, Soo-Ki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 2, 01.01.2004, p. 541-544.

Research output: Contribution to journalArticle

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