Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy

Part i

Jee Sun Yang, Doona Song, Boah Lee, Won Jin Ko, Song Kyu Park, Misun Won, Kiho Lee, Hwan Mook Kim, Gyoonhee Han

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.

Original languageEnglish
Pages (from-to)2861-2866
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Volume46
Issue number7
DOIs
Publication statusPublished - 2011 Jul 1

Fingerprint

Chemotherapy
Bioactivity
Ammonium Compounds
Antineoplastic Agents
Salts
Drug Therapy
ras Genes
Chain length
Carbon
Genes
Cells
Apoptosis
Neoplasms
compound 17

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Yang, Jee Sun ; Song, Doona ; Lee, Boah ; Ko, Won Jin ; Park, Song Kyu ; Won, Misun ; Lee, Kiho ; Kim, Hwan Mook ; Han, Gyoonhee. / Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy : Part i. In: European Journal of Medicinal Chemistry. 2011 ; Vol. 46, No. 7. pp. 2861-2866.
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Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy : Part i. / Yang, Jee Sun; Song, Doona; Lee, Boah; Ko, Won Jin; Park, Song Kyu; Won, Misun; Lee, Kiho; Kim, Hwan Mook; Han, Gyoonhee.

In: European Journal of Medicinal Chemistry, Vol. 46, No. 7, 01.07.2011, p. 2861-2866.

Research output: Contribution to journalArticle

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