We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.
Bibliographical noteFunding Information:
This research was supported by the 21st Century Frontier for Functional Analysis of the Human Genome , National Research Foundation ( 2009-0092966 ), Korean Research WCU Grant ( R31-2008-000-10086-0 ) and the Brain Korea 21 Project , of the Republic of Korea.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry