Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i

Jee Sun Yang; Doona Song; Boah Lee; Won Jin Ko; Song Kyu Park; Misun Won; Kiho Lee; Hwan Mook Kim; Gyoonhee Han

doi:10.1016/j.ejmech.2011.04.009

Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i

Jee Sun Yang, Doona Song, Boah Lee, Won Jin Ko, Song Kyu Park, Misun Won, Kiho Lee, Hwan Mook Kim, Gyoonhee Han

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.

Original language	English
Pages (from-to)	2861-2866
Number of pages	6
Journal	European Journal of Medicinal Chemistry
Volume	46
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2011.04.009
Publication status	Published - 2011 Jul 1

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All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Organic Chemistry

Cite this

Yang, J. S., Song, D., Lee, B., Ko, W. J., Park, S. K., Won, M., Lee, K., Kim, H. M., & Han, G. (2011). Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i. European Journal of Medicinal Chemistry, 46(7), 2861-2866. https://doi.org/10.1016/j.ejmech.2011.04.009

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Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy : Part i. / Yang, Jee Sun; Song, Doona; Lee, Boah; Ko, Won Jin; Park, Song Kyu; Won, Misun; Lee, Kiho; Kim, Hwan Mook; Han, Gyoonhee.

In: European Journal of Medicinal Chemistry, Vol. 46, No. 7, 01.07.2011, p. 2861-2866.

Research output: Contribution to journal › Article

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10.1016/j.ejmech.2011.04.009