Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i

Jee Sun Yang; Doona Song; Boah Lee; Won Jin Ko; Song Kyu Park; Misun Won; Kiho Lee; Hwan Mook Kim; Gyoonhee Han

doi:10.1016/j.ejmech.2011.04.009

Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i

Jee Sun Yang, Doona Song, Boah Lee, Won Jin Ko, Song Kyu Park, Misun Won, Kiho Lee, Hwan Mook Kim, Gyoonhee Han

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.

Original language	English
Pages (from-to)	2861-2866
Number of pages	6
Journal	European Journal of Medicinal Chemistry
Volume	46
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2011.04.009
Publication status	Published - 2011 Jul

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.ejmech.2011.04.009

Fingerprint Dive into the research topics of 'Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i'. Together they form a unique fingerprint.

Cite this

Yang, J. S., Song, D., Lee, B., Ko, W. J., Park, S. K., Won, M., Lee, K., Kim, H. M., & Han, G. (2011). Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i. European Journal of Medicinal Chemistry, 46(7), 2861-2866. https://doi.org/10.1016/j.ejmech.2011.04.009

@article{1b0f303624b141e1a103a7cc8e245720,

title = "Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i",

abstract = "We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.",

author = "Yang, {Jee Sun} and Doona Song and Boah Lee and Ko, {Won Jin} and Park, {Song Kyu} and Misun Won and Kiho Lee and Kim, {Hwan Mook} and Gyoonhee Han",

year = "2011",

month = jul,

doi = "10.1016/j.ejmech.2011.04.009",

language = "English",

volume = "46",

pages = "2861--2866",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson SAS",

number = "7",

}

Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy : Part i. / Yang, Jee Sun; Song, Doona; Lee, Boah; Ko, Won Jin; Park, Song Kyu; Won, Misun; Lee, Kiho; Kim, Hwan Mook; Han, Gyoonhee.

In: European Journal of Medicinal Chemistry, Vol. 46, No. 7, 07.2011, p. 2861-2866.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy

T2 - Part i

AU - Yang, Jee Sun

AU - Song, Doona

AU - Lee, Boah

AU - Ko, Won Jin

AU - Park, Song Kyu

AU - Won, Misun

AU - Lee, Kiho

AU - Kim, Hwan Mook

AU - Han, Gyoonhee

PY - 2011/7

Y1 - 2011/7

N2 - We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.

AB - We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.

UR - http://www.scopus.com/inward/record.url?scp=79957474685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957474685&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2011.04.009

DO - 10.1016/j.ejmech.2011.04.009

M3 - Article

C2 - 21543141

AN - SCOPUS:79957474685

VL - 46

SP - 2861

EP - 2866

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

IS - 7

ER -