Abstract
We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.
| Original language | English |
|---|---|
| Pages (from-to) | 2861-2866 |
| Number of pages | 6 |
| Journal | European Journal of Medicinal Chemistry |
| Volume | 46 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2011 Jul 1 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Drug Discovery
- Organic Chemistry
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Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy : Part i. / Yang, Jee Sun; Song, Doona; Lee, Boah; Ko, Won Jin; Park, Song Kyu; Won, Misun; Lee, Kiho; Kim, Hwan Mook; Han, Gyoonhee.
In: European Journal of Medicinal Chemistry, Vol. 46, No. 7, 01.07.2011, p. 2861-2866.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy
T2 - Part i
AU - Yang, Jee Sun
AU - Song, Doona
AU - Lee, Boah
AU - Ko, Won Jin
AU - Park, Song Kyu
AU - Won, Misun
AU - Lee, Kiho
AU - Kim, Hwan Mook
AU - Han, Gyoonhee
PY - 2011/7/1
Y1 - 2011/7/1
N2 - We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.
AB - We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.
UR - http://www.scopus.com/inward/record.url?scp=79957474685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957474685&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2011.04.009
DO - 10.1016/j.ejmech.2011.04.009
M3 - Article
VL - 46
SP - 2861
EP - 2866
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
SN - 0223-5234
IS - 7
ER -