Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i

Jee Sun Yang; Doona Song; Boah Lee; Won Jin Ko; Song Kyu Park; Misun Won; Kiho Lee; Hwan Mook Kim; Gyoonhee Han

doi:10.1016/j.ejmech.2011.04.009

Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i

Jee Sun Yang, Doona Song, Boah Lee, Won Jin Ko, Song Kyu Park, Misun Won, Kiho Lee, Hwan Mook Kim, Gyoonhee Han

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.

Original language	English
Pages (from-to)	2861-2866
Number of pages	6
Journal	European Journal of Medicinal Chemistry
Volume	46
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2011.04.009
Publication status	Published - 2011 Jul

Bibliographical note

Funding Information:
This research was supported by the 21st Century Frontier for Functional Analysis of the Human Genome , National Research Foundation ( 2009-0092966 ), Korean Research WCU Grant ( R31-2008-000-10086-0 ) and the Brain Korea 21 Project , of the Republic of Korea.

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2011.04.009

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title = "Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i",

abstract = "We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.",

author = "Yang, {Jee Sun} and Doona Song and Boah Lee and Ko, {Won Jin} and Park, {Song Kyu} and Misun Won and Kiho Lee and Kim, {Hwan Mook} and Gyoonhee Han",

note = "Funding Information: This research was supported by the 21st Century Frontier for Functional Analysis of the Human Genome , National Research Foundation ( 2009-0092966 ), Korean Research WCU Grant ( R31-2008-000-10086-0 ) and the Brain Korea 21 Project , of the Republic of Korea.",

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language = "English",

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T2 - Part i

AU - Yang, Jee Sun

AU - Song, Doona

AU - Lee, Boah

AU - Ko, Won Jin

AU - Park, Song Kyu

AU - Won, Misun

AU - Lee, Kiho

AU - Kim, Hwan Mook

AU - Han, Gyoonhee

N1 - Funding Information: This research was supported by the 21st Century Frontier for Functional Analysis of the Human Genome , National Research Foundation ( 2009-0092966 ), Korean Research WCU Grant ( R31-2008-000-10086-0 ) and the Brain Korea 21 Project , of the Republic of Korea.

PY - 2011/7

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AB - We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.

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Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part i

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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