Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy

Part II

Jee Sun Yang, Doona Song, Won Jin Ko, Bunyea Kim, Bo Kyung Kim, Song Kyu Park, Misun Won, Kiho Lee, Kyeong Lee, Hwan Mook Kim, Gyoonhee Han

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells.

Original languageEnglish
Pages (from-to)621-628
Number of pages8
JournalEuropean Journal of Medicinal Chemistry
Volume63
DOIs
Publication statusPublished - 2013 Apr 15

Fingerprint

Chemotherapy
Ammonium Compounds
Salts
Drug Therapy
Bromides
HeLa Cells
Human Activities
Chemical activation
Cells
Cell Line
Neoplasms
MB 3

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Yang, Jee Sun ; Song, Doona ; Ko, Won Jin ; Kim, Bunyea ; Kim, Bo Kyung ; Park, Song Kyu ; Won, Misun ; Lee, Kiho ; Lee, Kyeong ; Kim, Hwan Mook ; Han, Gyoonhee. / Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy : Part II. In: European Journal of Medicinal Chemistry. 2013 ; Vol. 63. pp. 621-628.
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Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy : Part II. / Yang, Jee Sun; Song, Doona; Ko, Won Jin; Kim, Bunyea; Kim, Bo Kyung; Park, Song Kyu; Won, Misun; Lee, Kiho; Lee, Kyeong; Kim, Hwan Mook; Han, Gyoonhee.

In: European Journal of Medicinal Chemistry, Vol. 63, 15.04.2013, p. 621-628.

Research output: Contribution to journalArticle

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