Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D3

Gyoonhee Han

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

A new series of phosphonate side chain analogues of 1α,25-dihydroxyvitamin D3 (1) have been synthesized. Antiproliferative activities of theses analogues (8a,b and 9a,b) using human keratinocyte cell shows that analogues which have natural A-ring show higher activity than unnatural A-ring series and almost equally active to 1α,25-Dihydroxyvitamin D3 (1) at 1 μM level.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalArchives of Pharmacal Research
Volume23
Issue number3
DOIs
Publication statusPublished - 2000 Jan 1

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Organophosphonates
Calcitriol
Keratinocytes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

Han, Gyoonhee. / Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D3 In: Archives of Pharmacal Research. 2000 ; Vol. 23, No. 3. pp. 206-210.
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Han, G 2000, 'Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D3 ', Archives of Pharmacal Research, vol. 23, no. 3, pp. 206-210. https://doi.org/10.1007/BF02976446

Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D3 . / Han, Gyoonhee.

In: Archives of Pharmacal Research, Vol. 23, No. 3, 01.01.2000, p. 206-210.

Research output: Contribution to journal › Article

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AB - A new series of phosphonate side chain analogues of 1α,25-dihydroxyvitamin D3 (1) have been synthesized. Antiproliferative activities of theses analogues (8a,b and 9a,b) using human keratinocyte cell shows that analogues which have natural A-ring show higher activity than unnatural A-ring series and almost equally active to 1α,25-Dihydroxyvitamin D3 (1) at 1 μM level.

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Han G. Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D3 Archives of Pharmacal Research. 2000 Jan 1;23(3):206-210. https://doi.org/10.1007/BF02976446

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