A new series of phosphonate side chain analogues of 1α,25-dihydroxyvitamin D3 (1) have been synthesized. Antiproliferative activities of theses analogues (8a,b and 9a,b) using human keratinocyte cell shows that analogues which have natural A-ring show higher activity than unnatural A-ring series and almost equally active to 1α,25-Dihydroxyvitamin D3 (1) at 1 μM level.
Bibliographical noteFunding Information:
I'd like to thank professor Gary Posner (chemistry) and professor Thomas Kensler (School of Hygene) at the Johns hopkins University for support and biological evaluation. This work was financially supported by the National Institute of Health (CA 44530).
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery
- Organic Chemistry