Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D3

Gyoonhee Han

doi:10.1007/BF02976446

Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D₃

Gyoonhee Han

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

A new series of phosphonate side chain analogues of 1α,25-dihydroxyvitamin D₃ (1) have been synthesized. Antiproliferative activities of theses analogues (8a,b and 9a,b) using human keratinocyte cell shows that analogues which have natural A-ring show higher activity than unnatural A-ring series and almost equally active to 1α,25-Dihydroxyvitamin D3 (1) at 1 μM level.

Original language	English
Pages (from-to)	206-210
Number of pages	5
Journal	Archives of pharmacal research
Volume	23
Issue number	3
DOIs	https://doi.org/10.1007/BF02976446
Publication status	Published - 2000

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery
Organic Chemistry

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Han, G. (2000). Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D₃. Archives of pharmacal research, 23(3), 206-210. https://doi.org/10.1007/BF02976446

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