Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D3

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A new series of phosphonate side chain analogues of 1α,25-dihydroxyvitamin D3 (1) have been synthesized. Antiproliferative activities of theses analogues (8a,b and 9a,b) using human keratinocyte cell shows that analogues which have natural A-ring show higher activity than unnatural A-ring series and almost equally active to 1α,25-Dihydroxyvitamin D3 (1) at 1 μM level.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalArchives of pharmacal research
Issue number3
Publication statusPublished - 2000 Jan 1


All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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