Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D3

Gyoonhee Han

doi:10.1007/BF02976446

Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D₃

Gyoonhee Han

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A new series of phosphonate side chain analogues of 1α,25-dihydroxyvitamin D₃ (1) have been synthesized. Antiproliferative activities of theses analogues (8a,b and 9a,b) using human keratinocyte cell shows that analogues which have natural A-ring show higher activity than unnatural A-ring series and almost equally active to 1α,25-Dihydroxyvitamin D3 (1) at 1 μM level.

Original language	English
Pages (from-to)	206-210
Number of pages	5
Journal	Archives of pharmacal research
Volume	23
Issue number	3
DOIs	https://doi.org/10.1007/BF02976446
Publication status	Published - 2000

Bibliographical note

Funding Information:
I'd like to thank professor Gary Posner (chemistry) and professor Thomas Kensler (School of Hygene) at the Johns hopkins University for support and biological evaluation. This work was financially supported by the National Institute of Health (CA 44530).

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery
Organic Chemistry

Access to Document

10.1007/BF02976446

Cite this

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title = "Synthesis and Biological Evaluation of Phosphonate Analogues of 1α, 25-Dihydroxyvitamin D3",

abstract = "A new series of phosphonate side chain analogues of 1α,25-dihydroxyvitamin D3 (1) have been synthesized. Antiproliferative activities of theses analogues (8a,b and 9a,b) using human keratinocyte cell shows that analogues which have natural A-ring show higher activity than unnatural A-ring series and almost equally active to 1α,25-Dihydroxyvitamin D3 (1) at 1 μM level.",

author = "Gyoonhee Han",

note = "Funding Information: I'd like to thank professor Gary Posner (chemistry) and professor Thomas Kensler (School of Hygene) at the Johns hopkins University for support and biological evaluation. This work was financially supported by the National Institute of Health (CA 44530).",

year = "2000",

doi = "10.1007/BF02976446",

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N1 - Funding Information: I'd like to thank professor Gary Posner (chemistry) and professor Thomas Kensler (School of Hygene) at the Johns hopkins University for support and biological evaluation. This work was financially supported by the National Institute of Health (CA 44530).

PY - 2000

Y1 - 2000

N2 - A new series of phosphonate side chain analogues of 1α,25-dihydroxyvitamin D3 (1) have been synthesized. Antiproliferative activities of theses analogues (8a,b and 9a,b) using human keratinocyte cell shows that analogues which have natural A-ring show higher activity than unnatural A-ring series and almost equally active to 1α,25-Dihydroxyvitamin D3 (1) at 1 μM level.

AB - A new series of phosphonate side chain analogues of 1α,25-dihydroxyvitamin D3 (1) have been synthesized. Antiproliferative activities of theses analogues (8a,b and 9a,b) using human keratinocyte cell shows that analogues which have natural A-ring show higher activity than unnatural A-ring series and almost equally active to 1α,25-Dihydroxyvitamin D3 (1) at 1 μM level.

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