Novel bifunctional fluorescent magneto polymeric nanoprobes (FMPNs) were synthesized to provide simultaneous diagnostic information via magnetic resonance imaging (MRI) and optical imaging. FMPNs consist of ultra-sensitive magnetic nanocrystals that function as MR probes combined with Nile Red, which functions as a fluorescent probe. FMPNs were encapsulated by a nano-emulsion method in polyvinyl alcohol (PVA, 87-89% hydrolyzed) through a matrix of polymethyl methacrylate (PMMA). FMPNs exhibited excellent colloidal stability and monodispersity. The production of MR and optical images demonstrated that FMPNs have potential as dual-mode imaging agents. Crown
Bibliographical noteFunding Information:
This work was supported by the Korea Science and Engineering Foundation grant funded by the Korea government ( M10755020001-07N5502-00110 ) and the Korea Health 21 R&D Project, Ministry of Health &Welfare (A085136), Yonsei University College of Medicine ( 6-2008-0223 ) and from KRIBB Research Intiative Program ( 7-2009-0326 ).
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Surfaces, Coatings and Films
- Colloid and Surface Chemistry