Synthesis and characterization of fluorescent magneto polymeric nanoparticles (FMPNs) for bimodal imaging probes

Joseph Park, Jaemoon Yang, Jaemin Lee, Eun Kyung Lim, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Novel bifunctional fluorescent magneto polymeric nanoprobes (FMPNs) were synthesized to provide simultaneous diagnostic information via magnetic resonance imaging (MRI) and optical imaging. FMPNs consist of ultra-sensitive magnetic nanocrystals that function as MR probes combined with Nile Red, which functions as a fluorescent probe. FMPNs were encapsulated by a nano-emulsion method in polyvinyl alcohol (PVA, 87-89% hydrolyzed) through a matrix of polymethyl methacrylate (PMMA). FMPNs exhibited excellent colloidal stability and monodispersity. The production of MR and optical images demonstrated that FMPNs have potential as dual-mode imaging agents. Crown

Original languageEnglish
Pages (from-to)176-181
Number of pages6
JournalJournal of Colloid and Interface Science
Volume340
Issue number2
DOIs
Publication statusPublished - 2009 Dec 15

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation grant funded by the Korea government ( M10755020001-07N5502-00110 ) and the Korea Health 21 R&D Project, Ministry of Health &Welfare (A085136), Yonsei University College of Medicine ( 6-2008-0223 ) and from KRIBB Research Intiative Program ( 7-2009-0326 ).

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

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