Multifunctional fluorescent and superparamagnetic Fe 3O 4/poly(fluorescein O-methacrylate) [Fe 3O 4/poly(FMA)] nanoparticles with core/shell structure were synthesized via surface-initiated polymerization. First, polymerizable double bonds were introduced onto the surface of Fe 3O 4 nanoparticles via ligand exchange and a condensation reaction. A fluorescent monomer, FMA, was then polymerized to the double bonds at the surface via free-radical polymerization, leading to form a fluorescent polymer shell around the superparamagnetic Fe 3O 4 core. The resultant Fe 3O 4/poly(FMA) nanoparticles were characterized by Fourier transform infrared, nuclear magnetic resonance, and X-ray diffraction spectroscopy to confirm the reactions. Transmission electron microscopy images showed that the Fe 3O 4/poly(FMA) nanoparticles have a spherical and monodisperse core/shell morphology. Photoluminescence spectroscopy and superconducting quantum interference device magnetometer analyses confirmed that the Fe 3O 4/poly(FMA) nanoparticles exhibited fluorescent and superparamagnetic properties, respectively. In addition, we demonstrated the potential bioimaging application of the Fe 3O 4/poly(FMA) nanoparticles by visualizing the cellular uptake of the nanoparticles into A549 lung cancer cells.
Bibliographical noteFunding Information:
This work was partly supported by a National Research Foundation (NRF) Grant funded by the Korea government (MEST) through the Active Polymer Center for Pattern Integration (No. R11-2007-050-00000-0). Additional funding was provided by the Pioneer Research Center Program though the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology (No. 2010-0019308/2011-0001670), and the Ministry of Education through the second-stage Brain Korea 21 Program at Yonsei University. This research was also supported by Nano Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (2011-0019176). This research was supported by the Converging Center Program through the Ministry of Education, Science, and Technology (2010K001430). The Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science, and Technology (2011-0023064), a Grant of the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A110416), and the Research Grant funded by the Gyeonggi Regional Research Center (GRRC) also contributed to this Project.
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Surfaces, Coatings and Films
- Colloid and Surface Chemistry