Synthesis and characterization of PEO-PCL-PEO triblock copolymers: Effects of the PCL chain length on the physical property of W1/O/W2 multiple emulsions

Heui Kyoung Cho, Kwang Soo Cho, Jin Hun Cho, Sung Wook Choi, Jung Hyun Kim, In Woo Cheong

Research output: Contribution to journalArticle

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Abstract

A series of poly(ethylene glycol)-block-poly(ε-caprolactone)-block-poly(ethylene glycol) (PEO-PCL-PEO) triblock copolymers were prepared and then used for the investigation of the effects of the ratio of ε-caprolactone to poly(ethylene glycol) (i.e., [CL]/[EO]) on the physical properties of water-in-oil-in-water (W1/O/W2) multiple emulsions containing a model reagent, ascorbic acid-2-glucoside (AA2G). In the synthesis, the [CL]/[EO] was varied from 0.11 to 0.31. The molecular weights and compositions of PEO-PCL-PEO were determined by GPC and 1H NMR analyses. Thermal behavior and crystal formation were studied by DSC, XRD, FT-IR, and polarized optical microscopy (POM). Aggregate behavior of PEO-PCL-PEO was confirmed by DLS, UV, and 1H NMR. Morphology and relative stiffness of the W1/O/W2 multiple emulsions in the presence of PEO-PCL-PEO were studied by confocal laser scanning microscopy (CLSM) and rheometer. Variation in the [CL]/[EO] significantly affects the crystalline temperature and spherulite morphology of PEO-PCL-PEO. As the [CL]/[EO] increases, the CMCs of PEO-PCL-PEO decreases and the slope of aggregate size reduction against the copolymer concentration becomes steeper except for the lowest [CL]/[EO] value of PEO-PCL-PEO (i.e., P-222). P-222 significantly increases the viscosity of continuous (W2) phase, which implies the copolymer would exist in the W2 phase. On the other hand, the triblock copolymers with relatively high [CL]/[EO] ratios mainly contribute to the size reduction of multiple emulsions and the formation of a firm wall structure. The particle size of the multiple emulsion decreases and the elastic modulus increased as [CL]/[EO] increases, confirmed by microscopic and rheometric analyses.

Original languageEnglish
Pages (from-to)61-68
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume65
Issue number1
DOIs
Publication statusPublished - 2008 Aug 1

Fingerprint

Polyethylene oxides
Emulsions
Chain length
Block copolymers
emulsions
copolymers
Physical properties
physical properties
glycols
ethylene
synthesis
Ethylene Glycol
Polyethylene glycols
microscopy
spherulites
glucosides
nuclear magnetic resonance
rheometers
ascorbic acid
water

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

@article{daac721534364df6b7935e9af7deb247,
title = "Synthesis and characterization of PEO-PCL-PEO triblock copolymers: Effects of the PCL chain length on the physical property of W1/O/W2 multiple emulsions",
abstract = "A series of poly(ethylene glycol)-block-poly(ε-caprolactone)-block-poly(ethylene glycol) (PEO-PCL-PEO) triblock copolymers were prepared and then used for the investigation of the effects of the ratio of ε-caprolactone to poly(ethylene glycol) (i.e., [CL]/[EO]) on the physical properties of water-in-oil-in-water (W1/O/W2) multiple emulsions containing a model reagent, ascorbic acid-2-glucoside (AA2G). In the synthesis, the [CL]/[EO] was varied from 0.11 to 0.31. The molecular weights and compositions of PEO-PCL-PEO were determined by GPC and 1H NMR analyses. Thermal behavior and crystal formation were studied by DSC, XRD, FT-IR, and polarized optical microscopy (POM). Aggregate behavior of PEO-PCL-PEO was confirmed by DLS, UV, and 1H NMR. Morphology and relative stiffness of the W1/O/W2 multiple emulsions in the presence of PEO-PCL-PEO were studied by confocal laser scanning microscopy (CLSM) and rheometer. Variation in the [CL]/[EO] significantly affects the crystalline temperature and spherulite morphology of PEO-PCL-PEO. As the [CL]/[EO] increases, the CMCs of PEO-PCL-PEO decreases and the slope of aggregate size reduction against the copolymer concentration becomes steeper except for the lowest [CL]/[EO] value of PEO-PCL-PEO (i.e., P-222). P-222 significantly increases the viscosity of continuous (W2) phase, which implies the copolymer would exist in the W2 phase. On the other hand, the triblock copolymers with relatively high [CL]/[EO] ratios mainly contribute to the size reduction of multiple emulsions and the formation of a firm wall structure. The particle size of the multiple emulsion decreases and the elastic modulus increased as [CL]/[EO] increases, confirmed by microscopic and rheometric analyses.",
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Synthesis and characterization of PEO-PCL-PEO triblock copolymers : Effects of the PCL chain length on the physical property of W1/O/W2 multiple emulsions. / Cho, Heui Kyoung; Cho, Kwang Soo; Cho, Jin Hun; Choi, Sung Wook; Kim, Jung Hyun; Cheong, In Woo.

In: Colloids and Surfaces B: Biointerfaces, Vol. 65, No. 1, 01.08.2008, p. 61-68.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and characterization of PEO-PCL-PEO triblock copolymers

T2 - Effects of the PCL chain length on the physical property of W1/O/W2 multiple emulsions

AU - Cho, Heui Kyoung

AU - Cho, Kwang Soo

AU - Cho, Jin Hun

AU - Choi, Sung Wook

AU - Kim, Jung Hyun

AU - Cheong, In Woo

PY - 2008/8/1

Y1 - 2008/8/1

N2 - A series of poly(ethylene glycol)-block-poly(ε-caprolactone)-block-poly(ethylene glycol) (PEO-PCL-PEO) triblock copolymers were prepared and then used for the investigation of the effects of the ratio of ε-caprolactone to poly(ethylene glycol) (i.e., [CL]/[EO]) on the physical properties of water-in-oil-in-water (W1/O/W2) multiple emulsions containing a model reagent, ascorbic acid-2-glucoside (AA2G). In the synthesis, the [CL]/[EO] was varied from 0.11 to 0.31. The molecular weights and compositions of PEO-PCL-PEO were determined by GPC and 1H NMR analyses. Thermal behavior and crystal formation were studied by DSC, XRD, FT-IR, and polarized optical microscopy (POM). Aggregate behavior of PEO-PCL-PEO was confirmed by DLS, UV, and 1H NMR. Morphology and relative stiffness of the W1/O/W2 multiple emulsions in the presence of PEO-PCL-PEO were studied by confocal laser scanning microscopy (CLSM) and rheometer. Variation in the [CL]/[EO] significantly affects the crystalline temperature and spherulite morphology of PEO-PCL-PEO. As the [CL]/[EO] increases, the CMCs of PEO-PCL-PEO decreases and the slope of aggregate size reduction against the copolymer concentration becomes steeper except for the lowest [CL]/[EO] value of PEO-PCL-PEO (i.e., P-222). P-222 significantly increases the viscosity of continuous (W2) phase, which implies the copolymer would exist in the W2 phase. On the other hand, the triblock copolymers with relatively high [CL]/[EO] ratios mainly contribute to the size reduction of multiple emulsions and the formation of a firm wall structure. The particle size of the multiple emulsion decreases and the elastic modulus increased as [CL]/[EO] increases, confirmed by microscopic and rheometric analyses.

AB - A series of poly(ethylene glycol)-block-poly(ε-caprolactone)-block-poly(ethylene glycol) (PEO-PCL-PEO) triblock copolymers were prepared and then used for the investigation of the effects of the ratio of ε-caprolactone to poly(ethylene glycol) (i.e., [CL]/[EO]) on the physical properties of water-in-oil-in-water (W1/O/W2) multiple emulsions containing a model reagent, ascorbic acid-2-glucoside (AA2G). In the synthesis, the [CL]/[EO] was varied from 0.11 to 0.31. The molecular weights and compositions of PEO-PCL-PEO were determined by GPC and 1H NMR analyses. Thermal behavior and crystal formation were studied by DSC, XRD, FT-IR, and polarized optical microscopy (POM). Aggregate behavior of PEO-PCL-PEO was confirmed by DLS, UV, and 1H NMR. Morphology and relative stiffness of the W1/O/W2 multiple emulsions in the presence of PEO-PCL-PEO were studied by confocal laser scanning microscopy (CLSM) and rheometer. Variation in the [CL]/[EO] significantly affects the crystalline temperature and spherulite morphology of PEO-PCL-PEO. As the [CL]/[EO] increases, the CMCs of PEO-PCL-PEO decreases and the slope of aggregate size reduction against the copolymer concentration becomes steeper except for the lowest [CL]/[EO] value of PEO-PCL-PEO (i.e., P-222). P-222 significantly increases the viscosity of continuous (W2) phase, which implies the copolymer would exist in the W2 phase. On the other hand, the triblock copolymers with relatively high [CL]/[EO] ratios mainly contribute to the size reduction of multiple emulsions and the formation of a firm wall structure. The particle size of the multiple emulsion decreases and the elastic modulus increased as [CL]/[EO] increases, confirmed by microscopic and rheometric analyses.

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