Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates

Milan Balaz, Andrea E. Holmes, Michele Benedetti, Pamela C. Rodriguez, Nina Berova, Koji Nakanishi, Gloria Proni

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75 Citations (Scopus)

Abstract

The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3- end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 Å), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA.

Original languageEnglish
Pages (from-to)4172-4173
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number12
DOIs
Publication statusPublished - 2005 Mar 30

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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    Balaz, M., Holmes, A. E., Benedetti, M., Rodriguez, P. C., Berova, N., Nakanishi, K., & Proni, G. (2005). Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates. Journal of the American Chemical Society, 127(12), 4172-4173. https://doi.org/10.1021/ja043373z