Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates

Milan Balaz, Andrea E. Holmes, Michele Benedetti, Pamela C. Rodriguez, Nina Berova, Koji Nakanishi, Gloria Proni

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3- end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 Å), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA.

Original languageEnglish
Pages (from-to)4172-4173
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number12
DOIs
Publication statusPublished - 2005 Mar 30

Fingerprint

Oligonucleotides
Porphyrins
Dichroism
Circular Dichroism
Excitons
DNA
DNA sequences
Chromophores
LDS 751

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Balaz, M., Holmes, A. E., Benedetti, M., Rodriguez, P. C., Berova, N., Nakanishi, K., & Proni, G. (2005). Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates. Journal of the American Chemical Society, 127(12), 4172-4173. https://doi.org/10.1021/ja043373z
Balaz, Milan ; Holmes, Andrea E. ; Benedetti, Michele ; Rodriguez, Pamela C. ; Berova, Nina ; Nakanishi, Koji ; Proni, Gloria. / Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates. In: Journal of the American Chemical Society. 2005 ; Vol. 127, No. 12. pp. 4172-4173.
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Balaz, M, Holmes, AE, Benedetti, M, Rodriguez, PC, Berova, N, Nakanishi, K & Proni, G 2005, 'Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates', Journal of the American Chemical Society, vol. 127, no. 12, pp. 4172-4173. https://doi.org/10.1021/ja043373z

Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates. / Balaz, Milan; Holmes, Andrea E.; Benedetti, Michele; Rodriguez, Pamela C.; Berova, Nina; Nakanishi, Koji; Proni, Gloria.

In: Journal of the American Chemical Society, Vol. 127, No. 12, 30.03.2005, p. 4172-4173.

Research output: Contribution to journalArticle

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T1 - Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates

AU - Balaz, Milan

AU - Holmes, Andrea E.

AU - Benedetti, Michele

AU - Rodriguez, Pamela C.

AU - Berova, Nina

AU - Nakanishi, Koji

AU - Proni, Gloria

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