Synthesis and evaluation of neuroprotective selenoflavanones

Yong Sung Choi; Dong Myung Kim; Yoon Jung Kim; Sai Yang; Kyung Tae Lee; Jong Hoon Ryu; Jin Hyun Jeong

doi:10.3390/ijms161226188

Synthesis and evaluation of neuroprotective selenoflavanones

Yong Sung Choi, Dong Myung Kim, Yoon Jung Kim, Sai Yang, Kyung Tae Lee, Jong Hoon Ryu, Jin Hyun Jeong

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.

Original language	English
Pages (from-to)	29574-29582
Number of pages	9
Journal	International journal of molecular sciences
Volume	16
Issue number	12
DOIs	https://doi.org/10.3390/ijms161226188
Publication status	Published - 2015 Dec 10

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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abstract = "The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.",

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AU - Kim, Dong Myung

AU - Kim, Yoon Jung

AU - Yang, Sai

AU - Lee, Kyung Tae

AU - Ryu, Jong Hoon

AU - Jeong, Jin Hyun

PY - 2015/12/10

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AB - The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.

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Synthesis and evaluation of neuroprotective selenoflavanones

Abstract

Bibliographical note

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