Synthesis and evaluation of neuroprotective selenoflavanones

Yong Sung Choi, Dong Myung Kim, Yoon Jung Kim, Sai Yang, Kyung Tae Lee, Jong Hoon Ryu, Jin-Hyun Jeong

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.

Original languageEnglish
Pages (from-to)29574-29582
Number of pages9
JournalInternational journal of molecular sciences
Volume16
Issue number12
DOIs
Publication statusPublished - 2015 Dec 10

Fingerprint

antioxidants
Antioxidants
Flavanones
infarction
blood-brain barrier
ischemia
Molecules
evaluation
Selenium
Neuroprotective Agents
synthesis
Cytotoxicity
selenium
Blood-Brain Barrier
hydrogen peroxide
Hydrogen peroxide
Infarction
Hydrogen Peroxide
mice
molecules

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Choi, Yong Sung ; Kim, Dong Myung ; Kim, Yoon Jung ; Yang, Sai ; Lee, Kyung Tae ; Ryu, Jong Hoon ; Jeong, Jin-Hyun. / Synthesis and evaluation of neuroprotective selenoflavanones. In: International journal of molecular sciences. 2015 ; Vol. 16, No. 12. pp. 29574-29582.
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Synthesis and evaluation of neuroprotective selenoflavanones. / Choi, Yong Sung; Kim, Dong Myung; Kim, Yoon Jung; Yang, Sai; Lee, Kyung Tae; Ryu, Jong Hoon; Jeong, Jin-Hyun.

In: International journal of molecular sciences, Vol. 16, No. 12, 10.12.2015, p. 29574-29582.

Research output: Contribution to journalArticle

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