Synthesis and evaluation of neuroprotective selenoflavanones

Yong Sung Choi, Dong Myung Kim, Yoon Jung Kim, Sai Yang, Kyung Tae Lee, Jong Hoon Ryu, Jin Hyun Jeong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.

Original languageEnglish
Pages (from-to)29574-29582
Number of pages9
JournalInternational journal of molecular sciences
Volume16
Issue number12
DOIs
Publication statusPublished - 2015 Dec 10

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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