Synthesis and evaluation of selenoflavones that have potential neuroprotective effects

Yong Sung Choi; Yoon Jung Kim; Ju Yeun Lee; Jinu Lee; Jin Hyun Jeong

doi:10.3987/COM-14-13112

Synthesis and evaluation of selenoflavones that have potential neuroprotective effects

Yong Sung Choi, Yoon Jung Kim, Ju Yeun Lee, Jinu Lee, Jin Hyun Jeong

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We synthesized selenoflavones and evaluated their physicochemical properties and antioxidant effects. When oxygen was substituted with selenium, the compounds exhibited improved polarity and lipophilicity, implying that this change could lead to better BBB penetration. Selenoflavones revealed more potent antioxidant activity in our in-vitro assay. This suggests that selenoflavones would be more druggable than flavones and have a better potential as a neuroprotective agent.

Original language	English
Pages (from-to)	2794-2805
Number of pages	12
Journal	Heterocycles
Volume	89
Issue number	12
DOIs	https://doi.org/10.3987/COM-14-13112
Publication status	Published - 2014

Bibliographical note

Publisher Copyright:
© 2014 The Japan Institute of Heterocyclic Chemistry.

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

Access to Document

10.3987/COM-14-13112

Cite this

@article{53b64069ef5a4ea78f7424d8af4c9244,

title = "Synthesis and evaluation of selenoflavones that have potential neuroprotective effects",

abstract = "We synthesized selenoflavones and evaluated their physicochemical properties and antioxidant effects. When oxygen was substituted with selenium, the compounds exhibited improved polarity and lipophilicity, implying that this change could lead to better BBB penetration. Selenoflavones revealed more potent antioxidant activity in our in-vitro assay. This suggests that selenoflavones would be more druggable than flavones and have a better potential as a neuroprotective agent.",

author = "Choi, {Yong Sung} and Kim, {Yoon Jung} and Lee, {Ju Yeun} and Jinu Lee and Jeong, {Jin Hyun}",

note = "Publisher Copyright: {\textcopyright} 2014 The Japan Institute of Heterocyclic Chemistry.",

year = "2014",

doi = "10.3987/COM-14-13112",

language = "English",

volume = "89",

pages = "2794--2805",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

number = "12",

}

TY - JOUR

T1 - Synthesis and evaluation of selenoflavones that have potential neuroprotective effects

AU - Choi, Yong Sung

AU - Kim, Yoon Jung

AU - Lee, Ju Yeun

AU - Lee, Jinu

AU - Jeong, Jin Hyun

PY - 2014

Y1 - 2014

N2 - We synthesized selenoflavones and evaluated their physicochemical properties and antioxidant effects. When oxygen was substituted with selenium, the compounds exhibited improved polarity and lipophilicity, implying that this change could lead to better BBB penetration. Selenoflavones revealed more potent antioxidant activity in our in-vitro assay. This suggests that selenoflavones would be more druggable than flavones and have a better potential as a neuroprotective agent.

AB - We synthesized selenoflavones and evaluated their physicochemical properties and antioxidant effects. When oxygen was substituted with selenium, the compounds exhibited improved polarity and lipophilicity, implying that this change could lead to better BBB penetration. Selenoflavones revealed more potent antioxidant activity in our in-vitro assay. This suggests that selenoflavones would be more druggable than flavones and have a better potential as a neuroprotective agent.

UR - http://www.scopus.com/inward/record.url?scp=84922261208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922261208&partnerID=8YFLogxK

U2 - 10.3987/COM-14-13112

DO - 10.3987/COM-14-13112

M3 - Article

AN - SCOPUS:84922261208

VL - 89

SP - 2794

EP - 2805

JO - Heterocycles

JF - Heterocycles

SN - 0385-5414

IS - 12

ER -

Synthesis and evaluation of selenoflavones that have potential neuroprotective effects

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this