Abstract
We synthesized selenoflavones and evaluated their physicochemical properties and antioxidant effects. When oxygen was substituted with selenium, the compounds exhibited improved polarity and lipophilicity, implying that this change could lead to better BBB penetration. Selenoflavones revealed more potent antioxidant activity in our in-vitro assay. This suggests that selenoflavones would be more druggable than flavones and have a better potential as a neuroprotective agent.
| Original language | English |
|---|---|
| Pages (from-to) | 2794-2805 |
| Number of pages | 12 |
| Journal | Heterocycles |
| Volume | 89 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Pharmacology
- Organic Chemistry
Cite this
}
Synthesis and evaluation of selenoflavones that have potential neuroprotective effects. / Choi, Yong Sung; Kim, Yoon Jung; Lee, Ju Yeun; Lee, Jinu; Jeong, Jin-Hyun.
In: Heterocycles, Vol. 89, No. 12, 01.01.2014, p. 2794-2805.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis and evaluation of selenoflavones that have potential neuroprotective effects
AU - Choi, Yong Sung
AU - Kim, Yoon Jung
AU - Lee, Ju Yeun
AU - Lee, Jinu
AU - Jeong, Jin-Hyun
PY - 2014/1/1
Y1 - 2014/1/1
N2 - We synthesized selenoflavones and evaluated their physicochemical properties and antioxidant effects. When oxygen was substituted with selenium, the compounds exhibited improved polarity and lipophilicity, implying that this change could lead to better BBB penetration. Selenoflavones revealed more potent antioxidant activity in our in-vitro assay. This suggests that selenoflavones would be more druggable than flavones and have a better potential as a neuroprotective agent.
AB - We synthesized selenoflavones and evaluated their physicochemical properties and antioxidant effects. When oxygen was substituted with selenium, the compounds exhibited improved polarity and lipophilicity, implying that this change could lead to better BBB penetration. Selenoflavones revealed more potent antioxidant activity in our in-vitro assay. This suggests that selenoflavones would be more druggable than flavones and have a better potential as a neuroprotective agent.
UR - http://www.scopus.com/inward/record.url?scp=84922261208&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922261208&partnerID=8YFLogxK
U2 - 10.3987/COM-14-13112
DO - 10.3987/COM-14-13112
M3 - Article
VL - 89
SP - 2794
EP - 2805
JO - Heterocycles
JF - Heterocycles
SN - 0385-5414
IS - 12
ER -