Synthesis and evaluation of selenoflavones that have potential neuroprotective effects

Yong Sung Choi; Yoon Jung Kim; Ju Yeun Lee; Jinu Lee; Jin Hyun Jeong

doi:10.3987/COM-14-13112

Synthesis and evaluation of selenoflavones that have potential neuroprotective effects

Yong Sung Choi, Yoon Jung Kim, Ju Yeun Lee, Jinu Lee, Jin Hyun Jeong

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We synthesized selenoflavones and evaluated their physicochemical properties and antioxidant effects. When oxygen was substituted with selenium, the compounds exhibited improved polarity and lipophilicity, implying that this change could lead to better BBB penetration. Selenoflavones revealed more potent antioxidant activity in our in-vitro assay. This suggests that selenoflavones would be more druggable than flavones and have a better potential as a neuroprotective agent.

Original language	English
Pages (from-to)	2794-2805
Number of pages	12
Journal	Heterocycles
Volume	89
Issue number	12
DOIs	https://doi.org/10.3987/COM-14-13112
Publication status	Published - 2014

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "We synthesized selenoflavones and evaluated their physicochemical properties and antioxidant effects. When oxygen was substituted with selenium, the compounds exhibited improved polarity and lipophilicity, implying that this change could lead to better BBB penetration. Selenoflavones revealed more potent antioxidant activity in our in-vitro assay. This suggests that selenoflavones would be more druggable than flavones and have a better potential as a neuroprotective agent.",

author = "Choi, {Yong Sung} and Kim, {Yoon Jung} and Lee, {Ju Yeun} and Jinu Lee and Jeong, {Jin Hyun}",

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AU - Kim, Yoon Jung

AU - Lee, Ju Yeun

AU - Lee, Jinu

AU - Jeong, Jin Hyun

PY - 2014

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