Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53

Seong Hee Moon, Youngeun Jung, Seong Hwan Kim, Ikyon Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Diversity-oriented construction of new indolizine scaffolds was accomplished by utilizing domino Knoevenagel condensation/intramolecular aldol cyclization. Biological evaluation revealed anticancer activity of these compounds through inhibition of β-catenin and activation of p53.

Original languageEnglish
Pages (from-to)110-113
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Catenins
Cyclization
Scaffolds
Condensation
Chemical activation
Derivatives
Neoplasms
indolizine
3-hydroxybutanal

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53. / Moon, Seong Hee; Jung, Youngeun; Kim, Seong Hwan; Kim, Ikyon.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 26, No. 1, 01.01.2016, p. 110-113.

Research output: Contribution to journalArticle

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