Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53

Seong Hee Moon, Youngeun Jung, Seong Hwan Kim, Ikyon Kim

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Diversity-oriented construction of new indolizine scaffolds was accomplished by utilizing domino Knoevenagel condensation/intramolecular aldol cyclization. Biological evaluation revealed anticancer activity of these compounds through inhibition of β-catenin and activation of p53.

Original languageEnglish
Pages (from-to)110-113
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIP) (2014R1A2A1A11050491) (to I.K.) and the Korea Research Institute of Chemical Technology project grant (SI1505) (to S.K.).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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