TY - JOUR
T1 - Synthesis of 2′,3′-dideoxyinosine via radical deoxygenation
AU - Torii, Takayoshi
AU - Izawa, Kunisuke
AU - Cho, Dae Hyan
AU - Jang, Doo Ok
PY - 2007/8
Y1 - 2007/8
N2 - A synthetic method for 2′,3′-dideoxyinosine (ddI) from inosine was established via radical deoxygenation of N1,5′-O-diprotected-2′, 3′-bis-S-methyl dithiocarbonate of inosine derivatives. The radical deoxygenation proceeded smoothly to give the desired dideoxy compounds in good yields using 1-ethylpiperidinium hypophosphite and triethylborane. Benzyl or p-methoxybenzyl protection of inosine at the N1, 5′-O-positions were effective for the ddI synthesis.
AB - A synthetic method for 2′,3′-dideoxyinosine (ddI) from inosine was established via radical deoxygenation of N1,5′-O-diprotected-2′, 3′-bis-S-methyl dithiocarbonate of inosine derivatives. The radical deoxygenation proceeded smoothly to give the desired dideoxy compounds in good yields using 1-ethylpiperidinium hypophosphite and triethylborane. Benzyl or p-methoxybenzyl protection of inosine at the N1, 5′-O-positions were effective for the ddI synthesis.
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U2 - 10.1080/15257770701508414
DO - 10.1080/15257770701508414
M3 - Article
C2 - 18058522
AN - SCOPUS:36849009107
SN - 1525-7770
VL - 26
SP - 985
EP - 988
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 8-9
ER -