Synthesis of 2′,3′-dideoxyinosine via radical deoxygenation

Takayoshi Torii, Kunisuke Izawa, Dae Hyan Cho, Doo Ok Jang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A synthetic method for 2′,3′-dideoxyinosine (ddI) from inosine was established via radical deoxygenation of N1,5′-O-diprotected-2′, 3′-bis-S-methyl dithiocarbonate of inosine derivatives. The radical deoxygenation proceeded smoothly to give the desired dideoxy compounds in good yields using 1-ethylpiperidinium hypophosphite and triethylborane. Benzyl or p-methoxybenzyl protection of inosine at the N1, 5′-O-positions were effective for the ddI synthesis.

Original languageEnglish
Pages (from-to)985-988
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume26
Issue number8-9
DOIs
Publication statusPublished - 2007 Aug

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Genetics

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