Synthesis of 2,3-disubstituted indole on solid phase by the fischer indole synthesis

Han S. Mun, Won H. Ham, Jin-Hyun Jeong

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

2,3-Disubstituted indoles were synthesized by solid-phase reaction using the Fischer indole synthesis. A "traceless" silicon linker was employed with the silicon - carbon bonding being cleaved with TFA. An oxygen atom was placed into the middle of the spacer/linker so as to enhance solid-phase synthesis by better solvation.

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalJournal of Combinatorial Chemistry
Volume7
Issue number1
DOIs
Publication statusPublished - 2005 Jan 1

Fingerprint

Silicon
Synthesis
Indoles
Solid-Phase Synthesis Techniques
Solvation
Oxygen
Carbon
Atoms
indole

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Organic Chemistry
  • Discrete Mathematics and Combinatorics
  • Drug Discovery

Cite this

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Synthesis of 2,3-disubstituted indole on solid phase by the fischer indole synthesis. / Mun, Han S.; Ham, Won H.; Jeong, Jin-Hyun.

In: Journal of Combinatorial Chemistry, Vol. 7, No. 1, 01.01.2005, p. 130-135.

Research output: Contribution to journalArticle

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N2 - 2,3-Disubstituted indoles were synthesized by solid-phase reaction using the Fischer indole synthesis. A "traceless" silicon linker was employed with the silicon - carbon bonding being cleaved with TFA. An oxygen atom was placed into the middle of the spacer/linker so as to enhance solid-phase synthesis by better solvation.

AB - 2,3-Disubstituted indoles were synthesized by solid-phase reaction using the Fischer indole synthesis. A "traceless" silicon linker was employed with the silicon - carbon bonding being cleaved with TFA. An oxygen atom was placed into the middle of the spacer/linker so as to enhance solid-phase synthesis by better solvation.

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