Synthesis of 6-Aryl-5-iodobenzo[e]pyrido[1,2-a]indoles by 6-endo-dig Iodocyclization

Youngeun Jung, Ikyon Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Regioselective access to 6-aryl-5-iodobenzo[e]pyrido[1,2-a]indoles was realized by using a facile 6-endo-dig iodine-mediated cyclization under mild reaction conditions. Further functionalization of the resulting products by using Pd-catalyzed coupling reactions was demonstrated, leading to the tetracyclic core substituted with two distinct functional groups in a regioselective fashion. Give me a ring! A range of 6-aryl-5-iodobenzo[e]pyrido[1,2-a]indoles were regioselectively synthesized by mild iodine-mediated cyclization. Further molecular diversity was achieved by reaction of the 5-iodo group in a Pd-catalyzed reaction.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalAsian Journal of Organic Chemistry
Volume5
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

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Indoles
Cyclization
Iodine
Functional groups

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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abstract = "Regioselective access to 6-aryl-5-iodobenzo[e]pyrido[1,2-a]indoles was realized by using a facile 6-endo-dig iodine-mediated cyclization under mild reaction conditions. Further functionalization of the resulting products by using Pd-catalyzed coupling reactions was demonstrated, leading to the tetracyclic core substituted with two distinct functional groups in a regioselective fashion. Give me a ring! A range of 6-aryl-5-iodobenzo[e]pyrido[1,2-a]indoles were regioselectively synthesized by mild iodine-mediated cyclization. Further molecular diversity was achieved by reaction of the 5-iodo group in a Pd-catalyzed reaction.",
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Synthesis of 6-Aryl-5-iodobenzo[e]pyrido[1,2-a]indoles by 6-endo-dig Iodocyclization. / Jung, Youngeun; Kim, Ikyon.

In: Asian Journal of Organic Chemistry, Vol. 5, No. 1, 01.01.2016, p. 147-152.

Research output: Contribution to journalArticle

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