Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities

Sang Sup Jew, Boon Saeng Park, Doo Yeon Lim, Myoung Goo Kim, In Kwon Chung, Joo Hee Kim, Chung Il Hong, Joon Kyum Kim, Hong Jun Park, Jun Hee Lee, Hyeung Geun Park

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.

Original languageEnglish
Pages (from-to)609-612
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number4
DOIs
Publication statusPublished - 2003 Feb

Fingerprint

Telomerase
Carboxylic Acids
Phenol
Functional groups
Tumors
Esters
Derivatives
Neoplasms
pyridine
aniline
2-formyl pyridine
thiophenol
3,4-dichlorothiophenol
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Jew, Sang Sup ; Park, Boon Saeng ; Lim, Doo Yeon ; Kim, Myoung Goo ; Chung, In Kwon ; Kim, Joo Hee ; Hong, Chung Il ; Kim, Joon Kyum ; Park, Hong Jun ; Lee, Jun Hee ; Park, Hyeung Geun. / Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 4. pp. 609-612.
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abstract = "Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.",
author = "Jew, {Sang Sup} and Park, {Boon Saeng} and Lim, {Doo Yeon} and Kim, {Myoung Goo} and Chung, {In Kwon} and Kim, {Joo Hee} and Hong, {Chung Il} and Kim, {Joon Kyum} and Park, {Hong Jun} and Lee, {Jun Hee} and Park, {Hyeung Geun}",
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Jew, SS, Park, BS, Lim, DY, Kim, MG, Chung, IK, Kim, JH, Hong, CI, Kim, JK, Park, HJ, Lee, JH & Park, HG 2003, 'Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities', Bioorganic and Medicinal Chemistry Letters, vol. 13, no. 4, pp. 609-612. https://doi.org/10.1016/S0960-894X(02)01041-7

Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities. / Jew, Sang Sup; Park, Boon Saeng; Lim, Doo Yeon; Kim, Myoung Goo; Chung, In Kwon; Kim, Joo Hee; Hong, Chung Il; Kim, Joon Kyum; Park, Hong Jun; Lee, Jun Hee; Park, Hyeung Geun.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 4, 02.2003, p. 609-612.

Research output: Contribution to journalArticle

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T1 - Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities

AU - Jew, Sang Sup

AU - Park, Boon Saeng

AU - Lim, Doo Yeon

AU - Kim, Myoung Goo

AU - Chung, In Kwon

AU - Kim, Joo Hee

AU - Hong, Chung Il

AU - Kim, Joon Kyum

AU - Park, Hong Jun

AU - Lee, Jun Hee

AU - Park, Hyeung Geun

PY - 2003/2

Y1 - 2003/2

N2 - Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.

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