Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities

Sang Sup Jew, Boon Saeng Park, Doo Yeon Lim, Myoung Goo Kim, In Kwon Chung, Joo Hee Kim, Chung Il Hong, Joon Kyum Kim, Hong Jun Park, Jun Hee Lee, Hyeung Geun Park

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34 Citations (Scopus)

Abstract

Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.

Original languageEnglish
Pages (from-to)609-612
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number4
DOIs
Publication statusPublished - 2003 Feb

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Jew, S. S., Park, B. S., Lim, D. Y., Kim, M. G., Chung, I. K., Kim, J. H., Hong, C. I., Kim, J. K., Park, H. J., Lee, J. H., & Park, H. G. (2003). Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities. Bioorganic and Medicinal Chemistry Letters, 13(4), 609-612. https://doi.org/10.1016/S0960-894X(02)01041-7