Synthesis of a AT base pair model in DNA and determination of hydrogen bonding strength on the formation of base triplet T:AT in CDCl3

Young Lag Cho; Kyu Sung Jeong

doi:10.1016/S0040-4039(97)10257-X

Synthesis of a AT base pair model in DNA and determination of hydrogen bonding strength on the formation of base triplet T:AT in CDCl₃

Young Lag Cho, Kyu Sung Jeong

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A molecular model has been synthesized to determine the hydrogen- bonding strength between AT and T in the base triplet, T:AT. A strong preference (>95%) of Watson-Crick mode along with 91% hydrogen-bonded conformation is observed in the model compound. The association constants of the AT model with 1-propyluracil and glutarimide are 15 M^-1 and 5.2 M^-1, respectively, in CDCl₃ at 296 ± 0.5 K. Negative cooperativity by pre- existing hydrogen bonds might be involved in the intermolecular binding events.

Original language	English
Pages (from-to)	8337-8340
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	48
DOIs	https://doi.org/10.1016/S0040-4039(97)10257-X
Publication status	Published - 1997 Dec 1

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(97)10257-X

Cite this

@article{9ec175e36fbb401ca15e4c78c2cccc39,

title = "Synthesis of a AT base pair model in DNA and determination of hydrogen bonding strength on the formation of base triplet T:AT in CDCl3",

abstract = "A molecular model has been synthesized to determine the hydrogen- bonding strength between AT and T in the base triplet, T:AT. A strong preference (>95%) of Watson-Crick mode along with 91% hydrogen-bonded conformation is observed in the model compound. The association constants of the AT model with 1-propyluracil and glutarimide are 15 M-1 and 5.2 M-1, respectively, in CDCl3 at 296 ± 0.5 K. Negative cooperativity by pre- existing hydrogen bonds might be involved in the intermolecular binding events.",

author = "Cho, {Young Lag} and Jeong, {Kyu Sung}",

year = "1997",

month = dec,

day = "1",

doi = "10.1016/S0040-4039(97)10257-X",

language = "English",

volume = "38",

pages = "8337--8340",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "48",

}

TY - JOUR

T1 - Synthesis of a AT base pair model in DNA and determination of hydrogen bonding strength on the formation of base triplet T:AT in CDCl3

AU - Cho, Young Lag

AU - Jeong, Kyu Sung

PY - 1997/12/1

Y1 - 1997/12/1

N2 - A molecular model has been synthesized to determine the hydrogen- bonding strength between AT and T in the base triplet, T:AT. A strong preference (>95%) of Watson-Crick mode along with 91% hydrogen-bonded conformation is observed in the model compound. The association constants of the AT model with 1-propyluracil and glutarimide are 15 M-1 and 5.2 M-1, respectively, in CDCl3 at 296 ± 0.5 K. Negative cooperativity by pre- existing hydrogen bonds might be involved in the intermolecular binding events.

AB - A molecular model has been synthesized to determine the hydrogen- bonding strength between AT and T in the base triplet, T:AT. A strong preference (>95%) of Watson-Crick mode along with 91% hydrogen-bonded conformation is observed in the model compound. The association constants of the AT model with 1-propyluracil and glutarimide are 15 M-1 and 5.2 M-1, respectively, in CDCl3 at 296 ± 0.5 K. Negative cooperativity by pre- existing hydrogen bonds might be involved in the intermolecular binding events.

UR - http://www.scopus.com/inward/record.url?scp=0000251944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0000251944&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(97)10257-X

DO - 10.1016/S0040-4039(97)10257-X

M3 - Article

AN - SCOPUS:0000251944

SN - 0040-4039

VL - 38

SP - 8337

EP - 8340

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 48

ER -

Synthesis of a AT base pair model in DNA and determination of hydrogen bonding strength on the formation of base triplet T:AT in CDCl₃

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this