Synthesis of a fluorescent and star-shaped 4-arm PEG with different functional groups at its ends

Dong Ik Lee, Chan Jin Kim, Chang Ha Lee, Ik Sung Ahn

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Dityrosine (DY), which is fluorescent and biocompatible, has multiple functional groups, including two amine and two carboxylic acid groups. By conjugating PEG arms to DY, we successfully synthesized a star-shaped 4-arm PEG with two carboxylic acid and two amine groups at its four ends. Two different kinds of molecules could be further linked to this 4-arm PEG.The chemical structures and molecular weights of the intermediate 2-arm PEG and 4-arm PEG were determined by 1H NMR spectroscopy and matrix assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS).

Original languageEnglish
Pages (from-to)1186-1190
Number of pages5
JournalJournal of Industrial and Engineering Chemistry
Volume18
Issue number3
DOIs
Publication statusPublished - 2012 May 25

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Functional groups
Polyethylene glycols
Stars
Carboxylic Acids
Carboxylic acids
Amines
Nuclear magnetic resonance spectroscopy
Ionization
Mass spectrometry
Desorption
Molecular weight
Molecules
Lasers
dityrosine

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

Cite this

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abstract = "Dityrosine (DY), which is fluorescent and biocompatible, has multiple functional groups, including two amine and two carboxylic acid groups. By conjugating PEG arms to DY, we successfully synthesized a star-shaped 4-arm PEG with two carboxylic acid and two amine groups at its four ends. Two different kinds of molecules could be further linked to this 4-arm PEG.The chemical structures and molecular weights of the intermediate 2-arm PEG and 4-arm PEG were determined by 1H NMR spectroscopy and matrix assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS).",
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Synthesis of a fluorescent and star-shaped 4-arm PEG with different functional groups at its ends. / Lee, Dong Ik; Kim, Chan Jin; Lee, Chang Ha; Ahn, Ik Sung.

In: Journal of Industrial and Engineering Chemistry, Vol. 18, No. 3, 25.05.2012, p. 1186-1190.

Research output: Contribution to journalArticle

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