A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
Bibliographical noteFunding Information:
This research was supported by the Korea Science and Engineering Foundation (KOSEF) grant (M10601000155) and Seoul R&BD Program (10541), Korea.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry