Synthesis of Amides and Phthalimides via a Palladium Catalyzed Aminocarbonylation of Aryl Halides with Formic Acid and Carbodiimides

Yong Sik Seo, Dong Su Kim, Chul Ho Jun

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A novel method for the preparation of amides and phthalimides has been developed. The process involves a palladium catalyzed aminocarbonylation of an aryl halide, using a carbodiimide and formic acid as the carbonyl source. Experimental data suggest that the mechanistic pathway for this process involves in-situ generation of carbon monoxide from the reaction of formic acid with a carbodiimide in the presence of a palladium catalyst. The method can be used to produce a variety of amides and N-substituted phthalimides efficiently.

Original languageEnglish
Pages (from-to)3508-3512
Number of pages5
JournalChemistry - An Asian Journal
Volume11
Issue number24
DOIs
Publication statusPublished - 2016 Dec 19

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formic acid
Phthalimides
Carbodiimides
Palladium
Amides
Carbon Monoxide
Catalysts

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

Cite this

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Synthesis of Amides and Phthalimides via a Palladium Catalyzed Aminocarbonylation of Aryl Halides with Formic Acid and Carbodiimides. / Seo, Yong Sik; Kim, Dong Su; Jun, Chul Ho.

In: Chemistry - An Asian Journal, Vol. 11, No. 24, 19.12.2016, p. 3508-3512.

Research output: Contribution to journalArticle

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