Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line

Junsang Lee, Bong Soo Nam, Hwan Kim, Chang Hyun Oh, So Ha Lee, Seung Joo Cho, Tae Bo Sim, Jung Mi Hah, Dong Jin Kim, Jinsung Tae, Kyung Ho Yoo

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The synthesis of a novel series of aminoquinazoline derivatives 1a-r and their antiproliferative activities against A375 human melanoma cell line were described. Among them, six compounds showed superior antiproliferative activities to Sorafenib as a reference compound. In particular, the representative compound 1q bearing chromen-4-one moiety exhibited excellent antiproliferative activity (IC50 = 0.006 μM) and good selectivity over HS27 fibroblast cell line.

Original languageEnglish
Pages (from-to)5722-5725
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number19
DOIs
Publication statusPublished - 2010 Oct 1

Bibliographical note

Funding Information:
This research was supported by a grant ( K00060-282 ) from the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea .

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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