Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line

Junsang Lee, Bong Soo Nam, Hwan Kim, Chang Hyun Oh, So Ha Lee, Seung Joo Cho, Tae Bo Sim, Jung Mi Hah, Dong Jin Kim, Jinsung Tae, Kyung Ho Yoo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The synthesis of a novel series of aminoquinazoline derivatives 1a-r and their antiproliferative activities against A375 human melanoma cell line were described. Among them, six compounds showed superior antiproliferative activities to Sorafenib as a reference compound. In particular, the representative compound 1q bearing chromen-4-one moiety exhibited excellent antiproliferative activity (IC50 = 0.006 μM) and good selectivity over HS27 fibroblast cell line.

Original languageEnglish
Pages (from-to)5722-5725
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number19
DOIs
Publication statusPublished - 2010 Oct 1

Fingerprint

Melanoma
Bearings (structural)
Thermodynamic properties
Cells
Derivatives
Cell Line
Fibroblasts
Inhibitory Concentration 50
sorafenib

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Lee, Junsang ; Nam, Bong Soo ; Kim, Hwan ; Oh, Chang Hyun ; Lee, So Ha ; Cho, Seung Joo ; Sim, Tae Bo ; Hah, Jung Mi ; Kim, Dong Jin ; Tae, Jinsung ; Yoo, Kyung Ho. / Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 19. pp. 5722-5725.
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Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line. / Lee, Junsang; Nam, Bong Soo; Kim, Hwan; Oh, Chang Hyun; Lee, So Ha; Cho, Seung Joo; Sim, Tae Bo; Hah, Jung Mi; Kim, Dong Jin; Tae, Jinsung; Yoo, Kyung Ho.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 19, 01.10.2010, p. 5722-5725.

Research output: Contribution to journalArticle

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