Synthesis of cell structures

Kyle Hammerick, Won Hyoung Ryu, Rainer Fasching, Seoung Jai Bai, R. Lane Smith, Ralph S. Greco, Fritz B. Prinz

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

The shortage of organs for transplantation has provided the impetus for increasing investigation into the development of artificial organs. Organs themselves consist of three-dimesional structures made up of cells with different degrees of specialization, an extracellular matrix, and a variety of tubes and ducts to transport their products and waste into the blood stream. One can imagine the need for an artificial pancreas to treat patients with type I diabetes mellitus, an artificial liver to treat acute fulminant hepatitis and as a bridge to transplantation for other liver diseases, an artificial kidney to replace dialysis, artificial hearts and lungs, artificial skin, artificial endocrine glands, artificial reproductive organs, and artificial vision. The inherent complexity of each of these devices is related to both the incorporation of cells and our ability to create three-dimensional structures for them. Autologous cells, which would not require immunosuppression, create a need for complex processes to harvest the host’s own cells, when available, and require additional interventions. The use of homologous cells or xenogeneic cells creates a level of complexity, immunologically, for which there clearly is not a simple solution. Nevertheless, the quest for artificial organs will continue unabated, and the possibility that microfabrication and nanotechnology can contribute to this process is substantial.

Original languageEnglish
Title of host publicationNanoscale Technology in Biological Systems
PublisherCRC Press
Pages73-101
Number of pages29
ISBN (Electronic)9780203500224
ISBN (Print)9780849319402
DOIs
Publication statusPublished - 2004 Jan 1

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Engineering(all)
  • Materials Science(all)

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  • Cite this

    Hammerick, K., Ryu, W. H., Fasching, R., Bai, S. J., Lane Smith, R., Greco, R. S., & Prinz, F. B. (2004). Synthesis of cell structures. In Nanoscale Technology in Biological Systems (pp. 73-101). CRC Press. https://doi.org/10.1201/9780203500224