Abstract
The shortage of organs for transplantation has provided the impetus for increasing investigation into the development of artificial organs. Organs themselves consist of three-dimesional structures made up of cells with different degrees of specialization, an extracellular matrix, and a variety of tubes and ducts to transport their products and waste into the blood stream. One can imagine the need for an artificial pancreas to treat patients with type I diabetes mellitus, an artificial liver to treat acute fulminant hepatitis and as a bridge to transplantation for other liver diseases, an artificial kidney to replace dialysis, artificial hearts and lungs, artificial skin, artificial endocrine glands, artificial reproductive organs, and artificial vision. The inherent complexity of each of these devices is related to both the incorporation of cells and our ability to create three-dimensional structures for them. Autologous cells, which would not require immunosuppression, create a need for complex processes to harvest the host’s own cells, when available, and require additional interventions. The use of homologous cells or xenogeneic cells creates a level of complexity, immunologically, for which there clearly is not a simple solution. Nevertheless, the quest for artificial organs will continue unabated, and the possibility that microfabrication and nanotechnology can contribute to this process is substantial.
| Original language | English |
|---|---|
| Title of host publication | Nanoscale Technology in Biological Systems |
| Publisher | CRC Press |
| Pages | 73-101 |
| Number of pages | 29 |
| ISBN (Electronic) | 9780203500224 |
| ISBN (Print) | 9780849319402 |
| DOIs | |
| Publication status | Published - 2004 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
- Engineering(all)
- Materials Science(all)
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Synthesis of cell structures. / Hammerick, Kyle; Ryu, Won Hyoung; Fasching, Rainer; Bai, Seoung Jai; Lane Smith, R.; Greco, Ralph S.; Prinz, Fritz B.
Nanoscale Technology in Biological Systems. CRC Press, 2004. p. 73-101.Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Synthesis of cell structures
AU - Hammerick, Kyle
AU - Ryu, Won Hyoung
AU - Fasching, Rainer
AU - Bai, Seoung Jai
AU - Lane Smith, R.
AU - Greco, Ralph S.
AU - Prinz, Fritz B.
PY - 2004/1/1
Y1 - 2004/1/1
N2 - The shortage of organs for transplantation has provided the impetus for increasing investigation into the development of artificial organs. Organs themselves consist of three-dimesional structures made up of cells with different degrees of specialization, an extracellular matrix, and a variety of tubes and ducts to transport their products and waste into the blood stream. One can imagine the need for an artificial pancreas to treat patients with type I diabetes mellitus, an artificial liver to treat acute fulminant hepatitis and as a bridge to transplantation for other liver diseases, an artificial kidney to replace dialysis, artificial hearts and lungs, artificial skin, artificial endocrine glands, artificial reproductive organs, and artificial vision. The inherent complexity of each of these devices is related to both the incorporation of cells and our ability to create three-dimensional structures for them. Autologous cells, which would not require immunosuppression, create a need for complex processes to harvest the host’s own cells, when available, and require additional interventions. The use of homologous cells or xenogeneic cells creates a level of complexity, immunologically, for which there clearly is not a simple solution. Nevertheless, the quest for artificial organs will continue unabated, and the possibility that microfabrication and nanotechnology can contribute to this process is substantial.
AB - The shortage of organs for transplantation has provided the impetus for increasing investigation into the development of artificial organs. Organs themselves consist of three-dimesional structures made up of cells with different degrees of specialization, an extracellular matrix, and a variety of tubes and ducts to transport their products and waste into the blood stream. One can imagine the need for an artificial pancreas to treat patients with type I diabetes mellitus, an artificial liver to treat acute fulminant hepatitis and as a bridge to transplantation for other liver diseases, an artificial kidney to replace dialysis, artificial hearts and lungs, artificial skin, artificial endocrine glands, artificial reproductive organs, and artificial vision. The inherent complexity of each of these devices is related to both the incorporation of cells and our ability to create three-dimensional structures for them. Autologous cells, which would not require immunosuppression, create a need for complex processes to harvest the host’s own cells, when available, and require additional interventions. The use of homologous cells or xenogeneic cells creates a level of complexity, immunologically, for which there clearly is not a simple solution. Nevertheless, the quest for artificial organs will continue unabated, and the possibility that microfabrication and nanotechnology can contribute to this process is substantial.
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UR - http://www.scopus.com/inward/citedby.url?scp=33751410909&partnerID=8YFLogxK
U2 - 10.1201/9780203500224
DO - 10.1201/9780203500224
M3 - Chapter
AN - SCOPUS:33751410909
SN - 9780849319402
SP - 73
EP - 101
BT - Nanoscale Technology in Biological Systems
PB - CRC Press
ER -