Synthesis of curcumin/polyrhodanine nanocapsules with antimicrobial properties by oxidative polymerization using the Fenton reaction

Jun Won Kook; Soyeon Kim; Jun Young Lee; Jung Hyun Kim

doi:10.1016/j.reactfunctpolym.2016.10.016

Synthesis of curcumin/polyrhodanine nanocapsules with antimicrobial properties by oxidative polymerization using the Fenton reaction

Jun Won Kook, Soyeon Kim, Jun Young Lee, Jung Hyun Kim

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Curcumin exhibits various biological activities; however, its applications are limited because of its poor water solubility. In this study, we describe an encapsulation process that improves this property using a polyrhodanine shell material synthesized by oxidative polymerization. Unlike the previous methods of oxidative polymerizations, we used the Fenton reaction to introduce a FeCl₃/H₂O₂ combination system. By changing the rhodanine monomer ratio, the curcumin/polyrhodanine nanocapsule (CPR-NC) shell thickness could be controlled. The release behavior of curcumin was characterized by UV–Vis spectroscopy over time. Antimicrobial tests with curcumin, polyrhodanine, and CPR-NC were performed to analyze the minimum inhibitory concentration and inhibition zones.

Original language	English
Pages (from-to)	125-130
Number of pages	6
Journal	Reactive and Functional Polymers
Volume	109
DOIs	https://doi.org/10.1016/j.reactfunctpolym.2016.10.016
Publication status	Published - 2016 Dec 1

Bibliographical note

Funding Information:
This work was supported by the Ministry of Trade Industry and Energy/Korea Evaluation Institute of Industrial Technology ( KEIT ) ( 10050039 ), and the Nano-Material Technology Development Program through the National Research Foundation of Korea ( NRF ) funded by the Ministry of Science, ICT & Future Planning (MSIP, Korea) (NRF- 2014M3A7B4050960 / 2014M3A7B4051745 ). The first two authors Jun.-Won Kook and Soyeon Kim contributed equally to this work.

Publisher Copyright:
© 2016 Elsevier B.V.

All Science Journal Classification (ASJC) codes

Chemistry(all)
Environmental Chemistry
Biochemistry
Chemical Engineering(all)
Polymers and Plastics
Materials Chemistry

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10.1016/j.reactfunctpolym.2016.10.016

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title = "Synthesis of curcumin/polyrhodanine nanocapsules with antimicrobial properties by oxidative polymerization using the Fenton reaction",

abstract = "Curcumin exhibits various biological activities; however, its applications are limited because of its poor water solubility. In this study, we describe an encapsulation process that improves this property using a polyrhodanine shell material synthesized by oxidative polymerization. Unlike the previous methods of oxidative polymerizations, we used the Fenton reaction to introduce a FeCl3/H2O2 combination system. By changing the rhodanine monomer ratio, the curcumin/polyrhodanine nanocapsule (CPR-NC) shell thickness could be controlled. The release behavior of curcumin was characterized by UV–Vis spectroscopy over time. Antimicrobial tests with curcumin, polyrhodanine, and CPR-NC were performed to analyze the minimum inhibitory concentration and inhibition zones.",

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N1 - Funding Information: This work was supported by the Ministry of Trade Industry and Energy/Korea Evaluation Institute of Industrial Technology ( KEIT ) ( 10050039 ), and the Nano-Material Technology Development Program through the National Research Foundation of Korea ( NRF ) funded by the Ministry of Science, ICT & Future Planning (MSIP, Korea) (NRF- 2014M3A7B4050960 / 2014M3A7B4051745 ). The first two authors Jun.-Won Kook and Soyeon Kim contributed equally to this work. Publisher Copyright: © 2016 Elsevier B.V.

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N2 - Curcumin exhibits various biological activities; however, its applications are limited because of its poor water solubility. In this study, we describe an encapsulation process that improves this property using a polyrhodanine shell material synthesized by oxidative polymerization. Unlike the previous methods of oxidative polymerizations, we used the Fenton reaction to introduce a FeCl3/H2O2 combination system. By changing the rhodanine monomer ratio, the curcumin/polyrhodanine nanocapsule (CPR-NC) shell thickness could be controlled. The release behavior of curcumin was characterized by UV–Vis spectroscopy over time. Antimicrobial tests with curcumin, polyrhodanine, and CPR-NC were performed to analyze the minimum inhibitory concentration and inhibition zones.

AB - Curcumin exhibits various biological activities; however, its applications are limited because of its poor water solubility. In this study, we describe an encapsulation process that improves this property using a polyrhodanine shell material synthesized by oxidative polymerization. Unlike the previous methods of oxidative polymerizations, we used the Fenton reaction to introduce a FeCl3/H2O2 combination system. By changing the rhodanine monomer ratio, the curcumin/polyrhodanine nanocapsule (CPR-NC) shell thickness could be controlled. The release behavior of curcumin was characterized by UV–Vis spectroscopy over time. Antimicrobial tests with curcumin, polyrhodanine, and CPR-NC were performed to analyze the minimum inhibitory concentration and inhibition zones.

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Synthesis of curcumin/polyrhodanine nanocapsules with antimicrobial properties by oxidative polymerization using the Fenton reaction

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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