Synthesis of daumone derivatives and their antiangiogenic activities on chorioallantoic membrane

Jeremy Ricci, Dongguk Min, Miyeon Oh, Hyenchong Lim, Won Yoon Chung, Kwang Kyun Park, Mankil Jung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.

Original languageEnglish
Pages (from-to)747-752
Number of pages6
JournalMedicinal Chemistry
Volume11
Issue number8
DOIs
Publication statusPublished - 2015 Dec 1

All Science Journal Classification (ASJC) codes

  • Drug Discovery

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