Abstract
Electroconductive hydrogels are composed of 3-dimensionally structured hydrogels and conducting molecules with electrical, optical, and reversible redox properties. These hybrid materials can be utilized as electrically-stimulated biomaterials in implantable biosensors or drug delivery systems. In this study, carbon nanotube-incorporated polyvinyl alcohol (PVA)-based hydrogels were synthesized by an electro-click reaction, which was controlled by an electrochemically generated Cu(i) catalyst. When the reduction potential of Cu(ii) ions was applied, PVA-based hydrogels were deposited onto indium-tin-oxide-coated glass electrodes via Cu(i)-catalysed alkyne-azide cycloaddition (click reaction). When the hydrogels contained carbon nanotubes, thicker films were deposited because the embedded carbon nanotubes provided a larger electrochemical active area. In addition, the carbon nanotubes improved the electrical conductivity of the hydrogel systems. We investigated the electro-stimulated drug release behaviour with electro-click conductive hydrogels using tetracycline as a model drug.
| Original language | English |
|---|---|
| Pages (from-to) | 4473-4478 |
| Number of pages | 6 |
| Journal | Polymer Chemistry |
| Volume | 6 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - 2015 Jun 28 |
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All Science Journal Classification (ASJC) codes
- Bioengineering
- Biochemistry
- Polymers and Plastics
- Organic Chemistry
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Synthesis of electroconductive hydrogel films by an electro-controlled click reaction and their application to drug delivery systems. / Choi, Eun Jung; Shin, Jisoo; Khaleel, Zinah Hilal; Cha, Inhwan; Yun, Sang Ho; Cho, Seung-Woo; Song, Changsik.
In: Polymer Chemistry, Vol. 6, No. 24, 28.06.2015, p. 4473-4478.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis of electroconductive hydrogel films by an electro-controlled click reaction and their application to drug delivery systems
AU - Choi, Eun Jung
AU - Shin, Jisoo
AU - Khaleel, Zinah Hilal
AU - Cha, Inhwan
AU - Yun, Sang Ho
AU - Cho, Seung-Woo
AU - Song, Changsik
PY - 2015/6/28
Y1 - 2015/6/28
N2 - Electroconductive hydrogels are composed of 3-dimensionally structured hydrogels and conducting molecules with electrical, optical, and reversible redox properties. These hybrid materials can be utilized as electrically-stimulated biomaterials in implantable biosensors or drug delivery systems. In this study, carbon nanotube-incorporated polyvinyl alcohol (PVA)-based hydrogels were synthesized by an electro-click reaction, which was controlled by an electrochemically generated Cu(i) catalyst. When the reduction potential of Cu(ii) ions was applied, PVA-based hydrogels were deposited onto indium-tin-oxide-coated glass electrodes via Cu(i)-catalysed alkyne-azide cycloaddition (click reaction). When the hydrogels contained carbon nanotubes, thicker films were deposited because the embedded carbon nanotubes provided a larger electrochemical active area. In addition, the carbon nanotubes improved the electrical conductivity of the hydrogel systems. We investigated the electro-stimulated drug release behaviour with electro-click conductive hydrogels using tetracycline as a model drug.
AB - Electroconductive hydrogels are composed of 3-dimensionally structured hydrogels and conducting molecules with electrical, optical, and reversible redox properties. These hybrid materials can be utilized as electrically-stimulated biomaterials in implantable biosensors or drug delivery systems. In this study, carbon nanotube-incorporated polyvinyl alcohol (PVA)-based hydrogels were synthesized by an electro-click reaction, which was controlled by an electrochemically generated Cu(i) catalyst. When the reduction potential of Cu(ii) ions was applied, PVA-based hydrogels were deposited onto indium-tin-oxide-coated glass electrodes via Cu(i)-catalysed alkyne-azide cycloaddition (click reaction). When the hydrogels contained carbon nanotubes, thicker films were deposited because the embedded carbon nanotubes provided a larger electrochemical active area. In addition, the carbon nanotubes improved the electrical conductivity of the hydrogel systems. We investigated the electro-stimulated drug release behaviour with electro-click conductive hydrogels using tetracycline as a model drug.
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U2 - 10.1039/c5py00545k
DO - 10.1039/c5py00545k
M3 - Article
VL - 6
SP - 4473
EP - 4478
JO - Polymer Chemistry
JF - Polymer Chemistry
SN - 1759-9954
IS - 24
ER -