Synthesis of electroconductive hydrogel films by an electro-controlled click reaction and their application to drug delivery systems

Eun Jung Choi, Jisoo Shin, Zinah Hilal Khaleel, Inhwan Cha, Sang Ho Yun, Seung Woo Cho, Changsik Song

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Electroconductive hydrogels are composed of 3-dimensionally structured hydrogels and conducting molecules with electrical, optical, and reversible redox properties. These hybrid materials can be utilized as electrically-stimulated biomaterials in implantable biosensors or drug delivery systems. In this study, carbon nanotube-incorporated polyvinyl alcohol (PVA)-based hydrogels were synthesized by an electro-click reaction, which was controlled by an electrochemically generated Cu(i) catalyst. When the reduction potential of Cu(ii) ions was applied, PVA-based hydrogels were deposited onto indium-tin-oxide-coated glass electrodes via Cu(i)-catalysed alkyne-azide cycloaddition (click reaction). When the hydrogels contained carbon nanotubes, thicker films were deposited because the embedded carbon nanotubes provided a larger electrochemical active area. In addition, the carbon nanotubes improved the electrical conductivity of the hydrogel systems. We investigated the electro-stimulated drug release behaviour with electro-click conductive hydrogels using tetracycline as a model drug.

Original languageEnglish
Pages (from-to)4473-4478
Number of pages6
JournalPolymer Chemistry
Volume6
Issue number24
DOIs
Publication statusPublished - 2015 Jun 28

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

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