Synthesis of laboratory ultrasound contrast agents

Jingam Park, Donghee Park, Unchul Shin, Sanghyub Moon, Chihyun Kim, Han Sung Kim, Hyunjin Park, Kiju Choi, Bong Kwang Jung, Jaemin Oh, Jongbum Seo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Ultrasound Contrast Agents (UCAs) were developed to maximize reflection contrast so that organs can be seen clearly in ultrasound imaging. UCAs increase the signal to noise ratio (SNR) by linear and non-linear mechanisms and thus help more accurately visualize the internal organs and blood vessels. However, the UCAs on the market are not only expensive, but are also not optimized for use in various therapeutic research applications such as ultrasound-aided drug delivery. The UCAs fabricated in this study utilize conventional lipid and albumin for shell formation and perfluorobutane as the internal gas. The shape and density of the UCA bubbles were verified by optical microscopy and Cryo SEM, and compared to those of the commercially available UCAs, Definity ® and Sonovue®. The size distribution and characteristics of the reflected signal were also analyzed using a particle size analyzer and ultrasound imaging equipment. Our experiments indicate that UCAs composed of spherical microbubbles, the majority of which were smaller than 1 um, were successfully synthesized. Microbubbles 10 um or larger were also identified when different shell characteristics and filters were used. These laboratory UCAs can be used for research in both diagnoses and therapies.

Original languageEnglish
Pages (from-to)13078-13095
Number of pages18
JournalMolecules
Volume18
Issue number10
DOIs
Publication statusPublished - 2013 Oct

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Park, J., Park, D., Shin, U., Moon, S., Kim, C., Kim, H. S., Park, H., Choi, K., Jung, B. K., Oh, J., & Seo, J. (2013). Synthesis of laboratory ultrasound contrast agents. Molecules, 18(10), 13078-13095. https://doi.org/10.3390/molecules181013078