Abstract
Iron oxide nanoparticles (IOs) are intrinsically theranostic agents that could be used for magnetic resonance imaging (MRI) and local hyperthermia or tissue thermal ablation. Yet, effective hyperthermia and high MR contrast have not been demonstrated within the same nanoparticle configuration. Here, magnetic nanoconstructs are obtained by confining multiple, ∼ 20 nm nanocubes (NCs) within a deoxy-chitosan core. The resulting nanoconstructs-magnetic nanoflakes (MNFs)-exhibit a hydrodynamic diameter of 156 ± 3.6 nm, with a polydispersity index of ∼0.2, and are stable in PBS up to 7 days. Upon exposure to an alternating magnetic field of 512 kHz and 10 kA m-1, MNFs provide a specific absorption rate (SAR) of ∼75 W gFe -1, which is 4-15 times larger than that measured for conventional IOs. Moreover, the same nanoconstructs provide a remarkably high transverse relaxivity of ∼500 (mM s)-1, at 1.41T. MNFs represent a first step toward the realization of nanoconstructs with superior relaxometric and ablation properties for more effective theranostics.
| Original language | English |
|---|---|
| Pages (from-to) | 12939-12946 |
| Number of pages | 8 |
| Journal | ACS Applied Materials and Interfaces |
| Volume | 6 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2014 Aug 13 |
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All Science Journal Classification (ASJC) codes
- Materials Science(all)
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Synthesis of multifunctional magnetic nanoflakes for magnetic resonance imaging, hyperthermia, and targeting. / Cervadoro, Antonio; Cho, Minjung; Key, Jaehong; Cooper, Christy; Stigliano, Cinzia; Aryal, Santosh; Brazdeikis, Audrius; Leary, James F.; Decuzzi, Paolo.
In: ACS Applied Materials and Interfaces, Vol. 6, No. 15, 13.08.2014, p. 12939-12946.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis of multifunctional magnetic nanoflakes for magnetic resonance imaging, hyperthermia, and targeting.
AU - Cervadoro, Antonio
AU - Cho, Minjung
AU - Key, Jaehong
AU - Cooper, Christy
AU - Stigliano, Cinzia
AU - Aryal, Santosh
AU - Brazdeikis, Audrius
AU - Leary, James F.
AU - Decuzzi, Paolo
PY - 2014/8/13
Y1 - 2014/8/13
N2 - Iron oxide nanoparticles (IOs) are intrinsically theranostic agents that could be used for magnetic resonance imaging (MRI) and local hyperthermia or tissue thermal ablation. Yet, effective hyperthermia and high MR contrast have not been demonstrated within the same nanoparticle configuration. Here, magnetic nanoconstructs are obtained by confining multiple, ∼ 20 nm nanocubes (NCs) within a deoxy-chitosan core. The resulting nanoconstructs-magnetic nanoflakes (MNFs)-exhibit a hydrodynamic diameter of 156 ± 3.6 nm, with a polydispersity index of ∼0.2, and are stable in PBS up to 7 days. Upon exposure to an alternating magnetic field of 512 kHz and 10 kA m-1, MNFs provide a specific absorption rate (SAR) of ∼75 W gFe -1, which is 4-15 times larger than that measured for conventional IOs. Moreover, the same nanoconstructs provide a remarkably high transverse relaxivity of ∼500 (mM s)-1, at 1.41T. MNFs represent a first step toward the realization of nanoconstructs with superior relaxometric and ablation properties for more effective theranostics.
AB - Iron oxide nanoparticles (IOs) are intrinsically theranostic agents that could be used for magnetic resonance imaging (MRI) and local hyperthermia or tissue thermal ablation. Yet, effective hyperthermia and high MR contrast have not been demonstrated within the same nanoparticle configuration. Here, magnetic nanoconstructs are obtained by confining multiple, ∼ 20 nm nanocubes (NCs) within a deoxy-chitosan core. The resulting nanoconstructs-magnetic nanoflakes (MNFs)-exhibit a hydrodynamic diameter of 156 ± 3.6 nm, with a polydispersity index of ∼0.2, and are stable in PBS up to 7 days. Upon exposure to an alternating magnetic field of 512 kHz and 10 kA m-1, MNFs provide a specific absorption rate (SAR) of ∼75 W gFe -1, which is 4-15 times larger than that measured for conventional IOs. Moreover, the same nanoconstructs provide a remarkably high transverse relaxivity of ∼500 (mM s)-1, at 1.41T. MNFs represent a first step toward the realization of nanoconstructs with superior relaxometric and ablation properties for more effective theranostics.
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U2 - 10.1021/am504270c
DO - 10.1021/am504270c
M3 - Article
C2 - 25003520
AN - SCOPUS:84906234948
VL - 6
SP - 12939
EP - 12946
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
IS - 15
ER -