Synthesis of multifunctional magnetic nanoflakes for magnetic resonance imaging, hyperthermia, and targeting.

Antonio Cervadoro, Minjung Cho, Jaehong Key, Christy Cooper, Cinzia Stigliano, Santosh Aryal, Audrius Brazdeikis, James F. Leary, Paolo Decuzzi

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Abstract

Iron oxide nanoparticles (IOs) are intrinsically theranostic agents that could be used for magnetic resonance imaging (MRI) and local hyperthermia or tissue thermal ablation. Yet, effective hyperthermia and high MR contrast have not been demonstrated within the same nanoparticle configuration. Here, magnetic nanoconstructs are obtained by confining multiple, ∼ 20 nm nanocubes (NCs) within a deoxy-chitosan core. The resulting nanoconstructs-magnetic nanoflakes (MNFs)-exhibit a hydrodynamic diameter of 156 ± 3.6 nm, with a polydispersity index of ∼0.2, and are stable in PBS up to 7 days. Upon exposure to an alternating magnetic field of 512 kHz and 10 kA m-1, MNFs provide a specific absorption rate (SAR) of ∼75 W gFe -1, which is 4-15 times larger than that measured for conventional IOs. Moreover, the same nanoconstructs provide a remarkably high transverse relaxivity of ∼500 (mM s)-1, at 1.41T. MNFs represent a first step toward the realization of nanoconstructs with superior relaxometric and ablation properties for more effective theranostics.

Original languageEnglish
Pages (from-to)12939-12946
Number of pages8
JournalACS Applied Materials and Interfaces
Volume6
Issue number15
DOIs
Publication statusPublished - 2014 Aug 13

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Cervadoro, A., Cho, M., Key, J., Cooper, C., Stigliano, C., Aryal, S., Brazdeikis, A., Leary, J. F., & Decuzzi, P. (2014). Synthesis of multifunctional magnetic nanoflakes for magnetic resonance imaging, hyperthermia, and targeting. ACS Applied Materials and Interfaces, 6(15), 12939-12946. https://doi.org/10.1021/am504270c