Synthesis of multifunctional magnetic nanoflakes for magnetic resonance imaging, hyperthermia, and targeting.

Antonio Cervadoro, Minjung Cho, Jaehong Key, Christy Cooper, Cinzia Stigliano, Santosh Aryal, Audrius Brazdeikis, James F. Leary, Paolo Decuzzi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Iron oxide nanoparticles (IOs) are intrinsically theranostic agents that could be used for magnetic resonance imaging (MRI) and local hyperthermia or tissue thermal ablation. Yet, effective hyperthermia and high MR contrast have not been demonstrated within the same nanoparticle configuration. Here, magnetic nanoconstructs are obtained by confining multiple, ∼ 20 nm nanocubes (NCs) within a deoxy-chitosan core. The resulting nanoconstructs-magnetic nanoflakes (MNFs)-exhibit a hydrodynamic diameter of 156 ± 3.6 nm, with a polydispersity index of ∼0.2, and are stable in PBS up to 7 days. Upon exposure to an alternating magnetic field of 512 kHz and 10 kA m-1, MNFs provide a specific absorption rate (SAR) of ∼75 W gFe -1, which is 4-15 times larger than that measured for conventional IOs. Moreover, the same nanoconstructs provide a remarkably high transverse relaxivity of ∼500 (mM s)-1, at 1.41T. MNFs represent a first step toward the realization of nanoconstructs with superior relaxometric and ablation properties for more effective theranostics.

Original languageEnglish
Pages (from-to)12939-12946
Number of pages8
JournalACS Applied Materials and Interfaces
Volume6
Issue number15
DOIs
Publication statusPublished - 2014 Aug 13

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Magnetic resonance
Ablation
Nanoparticles
Imaging techniques
Chitosan
Polydispersity
Iron oxides
Hydrodynamics
Tissue
Magnetic fields
Hot Temperature
ferric oxide

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Cervadoro, Antonio ; Cho, Minjung ; Key, Jaehong ; Cooper, Christy ; Stigliano, Cinzia ; Aryal, Santosh ; Brazdeikis, Audrius ; Leary, James F. ; Decuzzi, Paolo. / Synthesis of multifunctional magnetic nanoflakes for magnetic resonance imaging, hyperthermia, and targeting. In: ACS Applied Materials and Interfaces. 2014 ; Vol. 6, No. 15. pp. 12939-12946.
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Cervadoro, A, Cho, M, Key, J, Cooper, C, Stigliano, C, Aryal, S, Brazdeikis, A, Leary, JF & Decuzzi, P 2014, 'Synthesis of multifunctional magnetic nanoflakes for magnetic resonance imaging, hyperthermia, and targeting.', ACS Applied Materials and Interfaces, vol. 6, no. 15, pp. 12939-12946. https://doi.org/10.1021/am504270c

Synthesis of multifunctional magnetic nanoflakes for magnetic resonance imaging, hyperthermia, and targeting. / Cervadoro, Antonio; Cho, Minjung; Key, Jaehong; Cooper, Christy; Stigliano, Cinzia; Aryal, Santosh; Brazdeikis, Audrius; Leary, James F.; Decuzzi, Paolo.

In: ACS Applied Materials and Interfaces, Vol. 6, No. 15, 13.08.2014, p. 12939-12946.

Research output: Contribution to journalArticle

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AU - Cho, Minjung

AU - Key, Jaehong

AU - Cooper, Christy

AU - Stigliano, Cinzia

AU - Aryal, Santosh

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AU - Leary, James F.

AU - Decuzzi, Paolo

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