Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives

Youngjae Kim; Minjoo Kim; Mooseong Park; Jinsung Tae; Du Jong Baek; Ki Duk Park; Hyunah Choo

doi:10.3390/molecules20035074

Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives

Youngjae Kim, Minjoo Kim, Mooseong Park, Jinsung Tae, Du Jong Baek, Ki Duk Park, Hyunah Choo

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.

Original language	English
Pages (from-to)	5074-5084
Number of pages	11
Journal	Molecules
Volume	20
Issue number	3
DOIs	https://doi.org/10.3390/molecules20035074
Publication status	Published - 2015 Mar 1

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI.

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives",

abstract = "A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.",

author = "Youngjae Kim and Minjoo Kim and Mooseong Park and Jinsung Tae and Baek, {Du Jong} and Park, {Ki Duk} and Hyunah Choo",

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AU - Kim, Youngjae

AU - Kim, Minjoo

AU - Park, Mooseong

AU - Tae, Jinsung

AU - Baek, Du Jong

AU - Park, Ki Duk

AU - Choo, Hyunah

PY - 2015/3/1

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N2 - A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.

AB - A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.

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Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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