Abstract
A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 5074-5084 |
| Number of pages | 11 |
| Journal | Molecules |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 Mar 1 |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry
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Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives. / Kim, Youngjae; Kim, Minjoo; Park, Mooseong; Tae, Jinsung; Baek, Du Jong; Park, Ki Duk; Choo, Hyunah.
In: Molecules, Vol. 20, No. 3, 01.03.2015, p. 5074-5084.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives
AU - Kim, Youngjae
AU - Kim, Minjoo
AU - Park, Mooseong
AU - Tae, Jinsung
AU - Baek, Du Jong
AU - Park, Ki Duk
AU - Choo, Hyunah
PY - 2015/3/1
Y1 - 2015/3/1
N2 - A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.
AB - A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.
UR - http://www.scopus.com/inward/record.url?scp=84929603562&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929603562&partnerID=8YFLogxK
U2 - 10.3390/molecules20035074
DO - 10.3390/molecules20035074
M3 - Article
VL - 20
SP - 5074
EP - 5084
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 3
ER -