Abstract
A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 5074-5084 |
| Number of pages | 11 |
| Journal | Molecules |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 Mar 1 |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry
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Cite this
Kim, Y., Kim, M., Park, M., Tae, J., Baek, D. J., Park, K. D., & Choo, H. (2015). Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives. Molecules, 20(3), 5074-5084. https://doi.org/10.3390/molecules20035074