Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives

Youngjae Kim, Minjoo Kim, Mooseong Park, Jinsung Tae, Du Jong Baek, Ki Duk Park, Hyunah Choo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.

Original languageEnglish
Pages (from-to)5074-5084
Number of pages11
JournalMolecules
Volume20
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Kim, Y., Kim, M., Park, M., Tae, J., Baek, D. J., Park, K. D., & Choo, H. (2015). Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives. Molecules, 20(3), 5074-5084. https://doi.org/10.3390/molecules20035074