Synthesis of novel glycopeptidomimetics containing O- and N-glycosylated α-aminooxy acids by fragment coupling on solid support

Myung Ryul Lee; Jiyong Lee; Injae Shin

doi:10.1055/s-2002-33509

Synthesis of novel glycopeptidomimetics containing O- and N-glycosylated α-aminooxy acids by fragment coupling on solid support

Myung Ryul Lee, Jiyong Lee, Injae Shin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

New glycosylated peptidomimetics possessing O- and N-glycosylated α-aminooxy acids were efficiently synthesized by fragment coupling on solid support. The N-terminal glycosylated tripeptide mimics prepared in solution were coupled to the C-terminal dipeptides attached to the resin under O-(7-azabenzotriazole-I-yl)-1, 1, 3, 3-tetramethyluronium hexafluorophosphate (HATU)/1-hydroxy-7-azabenzotriazole (HOAt)/N-ethylmorpholin (NEM) conditions.

Original language	English
Pages (from-to)	1463-1466
Number of pages	4
Journal	Synlett
Issue number	9
DOIs	https://doi.org/10.1055/s-2002-33509
Publication status	Published - 2002

All Science Journal Classification (ASJC) codes

Organic Chemistry

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abstract = "New glycosylated peptidomimetics possessing O- and N-glycosylated α-aminooxy acids were efficiently synthesized by fragment coupling on solid support. The N-terminal glycosylated tripeptide mimics prepared in solution were coupled to the C-terminal dipeptides attached to the resin under O-(7-azabenzotriazole-I-yl)-1, 1, 3, 3-tetramethyluronium hexafluorophosphate (HATU)/1-hydroxy-7-azabenzotriazole (HOAt)/N-ethylmorpholin (NEM) conditions.",

author = "Lee, {Myung Ryul} and Jiyong Lee and Injae Shin",

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journal = "Synlett",

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AU - Lee, Jiyong

AU - Shin, Injae

PY - 2002

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N2 - New glycosylated peptidomimetics possessing O- and N-glycosylated α-aminooxy acids were efficiently synthesized by fragment coupling on solid support. The N-terminal glycosylated tripeptide mimics prepared in solution were coupled to the C-terminal dipeptides attached to the resin under O-(7-azabenzotriazole-I-yl)-1, 1, 3, 3-tetramethyluronium hexafluorophosphate (HATU)/1-hydroxy-7-azabenzotriazole (HOAt)/N-ethylmorpholin (NEM) conditions.

AB - New glycosylated peptidomimetics possessing O- and N-glycosylated α-aminooxy acids were efficiently synthesized by fragment coupling on solid support. The N-terminal glycosylated tripeptide mimics prepared in solution were coupled to the C-terminal dipeptides attached to the resin under O-(7-azabenzotriazole-I-yl)-1, 1, 3, 3-tetramethyluronium hexafluorophosphate (HATU)/1-hydroxy-7-azabenzotriazole (HOAt)/N-ethylmorpholin (NEM) conditions.

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JF - Synlett

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