Synthesis of polymers for a gene carrier by the ester-amide exchange method

Shigeto Fukushima, Naoki Kanayama, Kanjiro Miyata, Younsoo Bae, Masataka Nakanishi, Woo Dong Jang, Nobuhiro Nishiyama, Yuichi Yamasaki, Kazunori Kataoka

Research output: Contribution to conferencePaper

Abstract

Polyethylene glycol-polycation block copolymers, in which various kind of cationic side chains were introduced, were successfully synthesized by aminolysis of benzyl ester of polyethylene glycol-poly(β- benzyl-L-aspartate) block copolymer(PEG-PBLA)(ester-amide exchange method). Among them, some block copolymers showed the high transfection efficiency, and the mechanism and the characteristics of the ester-amide exchange reaction were investigated. This method is a very useful tool for design of non-viral gene carriers.

Original languageEnglish
Pages2208
Number of pages1
Publication statusPublished - 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Fukushima, S., Kanayama, N., Miyata, K., Bae, Y., Nakanishi, M., Jang, W. D., Nishiyama, N., Yamasaki, Y., & Kataoka, K. (2005). Synthesis of polymers for a gene carrier by the ester-amide exchange method. 2208. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.