Polyethylene glycol-polycation block copolymers, in which various kind of cationic side chains were introduced, were successfully synthesized by aminolysis of benzyl ester of polyethylene glycol-poly(β- benzyl-L-aspartate) block copolymer(PEG-PBLA)(ester-amide exchange method). Among them, some block copolymers showed the high transfection efficiency, and the mechanism and the characteristics of the ester-amide exchange reaction were investigated. This method is a very useful tool for design of non-viral gene carriers.
|Number of pages||1|
|Publication status||Published - 2005 Dec 1|
|Event||54th SPSJ Annual Meeting 2005 - Yokohama, Japan|
Duration: 2005 May 25 → 2005 May 27
|Other||54th SPSJ Annual Meeting 2005|
|Period||05/5/25 → 05/5/27|
All Science Journal Classification (ASJC) codes