Synthesis of selenopyrano[2,3-b]indol-4(9H)-ones and their C-H arylation

Choi Woo-Jin, Hitesh B. Jalani, Jin Hyun Jeong

Research output: Contribution to journalArticlepeer-review


Herein, we disclose the synthesis of selenopyrano[2,3-b]indol-4(9H)-ones and their aryl derivatives using seleno-pyran ring formation via an in situ-generated selenide reacting directly with α-halo-β-ynones of substituted indoles providing selenopyrano[2,3-b]indol-4(9H)-ones. Subsequent direct C-H arylation of the these compounds by palladium-catalyzed Heck reaction enables the incorporation of aryl substituents on the selenopyrano[2,3-b]indol-4(9H)-ones scaffolds with moderate yields. This new chemo-type incorporating an indole ring may be useful for the biological screenings.

Original languageEnglish
Pages (from-to)1430-1434
Number of pages5
JournalJournal of Heterocyclic Chemistry
Issue number8
Publication statusPublished - 2022 Aug

Bibliographical note

Funding Information:
This work was carried out as a co‐operation project of “Enhancement of Korea Chemical Bank (SI1807) supported by Korea Research Institute of Chemical Technology (KRICT) and Yonsei Institute of Pharmaceutical Sciences for financial support.

Publisher Copyright:
© 2022 Wiley Periodicals LLC.

All Science Journal Classification (ASJC) codes

  • Organic Chemistry


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