Herein, we disclose the synthesis of selenopyrano[2,3-b]indol-4(9H)-ones and their aryl derivatives using seleno-pyran ring formation via an in situ-generated selenide reacting directly with α-halo-β-ynones of substituted indoles providing selenopyrano[2,3-b]indol-4(9H)-ones. Subsequent direct C-H arylation of the these compounds by palladium-catalyzed Heck reaction enables the incorporation of aryl substituents on the selenopyrano[2,3-b]indol-4(9H)-ones scaffolds with moderate yields. This new chemo-type incorporating an indole ring may be useful for the biological screenings.
|Number of pages||5|
|Journal||Journal of Heterocyclic Chemistry|
|Publication status||Published - 2022 Aug|
Bibliographical noteFunding Information:
This work was carried out as a co‐operation project of “Enhancement of Korea Chemical Bank (SI1807) supported by Korea Research Institute of Chemical Technology (KRICT) and Yonsei Institute of Pharmaceutical Sciences for financial support.
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All Science Journal Classification (ASJC) codes
- Organic Chemistry