Synthesis of Selenopyrano[2,3- c ]pyrazol-4(1 H)-ones and Their C-H Activation

In Hui Choi, Hitesh B. Jalani, Jin Hyun Jeong

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


We disclose the synthesis of selenopyrano[2,3- c ]pyrazol-4(1 H)-ones and their aryl derivatives for the first time by using selenopyran ring formation via an in situ-generated selenide that reacts directly with α-halo-β-ynone-bearing substituted pyrazoles to provide the corresponding selenopyrano[2,3- c ]pyrazol-4(1 H)-ones. Subsequent direct C-H arylation of the latter compounds effected by palladium-catalyzed Heck reactions permits the incorporation of arene substituents onto the selenopyrano[2,3- c ]pyrazol-4(1 H)-ones scaffolds with moderate to good yields, and might be useful for biological screenings.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
Issue number3
Publication statusPublished - 2021 Feb 12

Bibliographical note

Funding Information:
This work was carried out as a co-operative project ‘Enhancement of Korea Chemical Bank (SI1807)’ financially supported by the Korea Research Institute of Chemical Technology (KRICT) and the Yonsei Institute of Pharmaceutical Sciences.KoeaReseachInstueofChemical TechnologySI1807)

Publisher Copyright:
© 2021 Georg Thieme Verlag. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Organic Chemistry


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