Synthesis of silicon traceless linker for solid-phase reaction

Han Seo Mun, Jin-Hyun Jeong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The silicon linker is the foremost traceless linker used in solid-phase reactions. Hydrogen fluoride (HF) or trifluoroacetic aicd (TFA) can remove the silicon linker with the silicon atom being replaced by a hydrogen atom. In this experiment, the linkers 1c and 2d, which are the most useful in solid-phase reactions, were synthesized. Linker 1c is composed of seven linearly linked carbons and linker 2d includes an oxygen atom in the linear carbon chain to increase the solvation capacity. The carboxylic acid component of linker 1c and 2d forms an amide or ester bond with resin. The synthesized linkers 1c and 2d could be utilized in constructing a chemical compound library that includes indole, benzodiazepine and phenothiazine (aromatic ring compounds).

Original languageEnglish
Pages (from-to)371-375
Number of pages5
JournalArchives of pharmacal research
Volume27
Issue number4
DOIs
Publication statusPublished - 2004 Apr 30

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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