Abstract
We have developed pyrene-modified magnetic polyaniline nanoparticles (MPANs), a hybridization of MnFe2O4 magnetic nanoparticles (MNPs) and polyaniline (PANI) with pyrene as a cross-linker, for diagnosis by simultaneous magnetic resonance (MR) imaging and photothermal therapy. In general, the strong affinity between PANI molecules, owing to interchain hydrogen bonding and the π-π interactions mediated by their aromatic composition, hinders the successful synthesis of complexes of PANI with inorganic materials. To overcome this obstacle, we used pyrene as a cross-linker to synthesize a stable complex of PANI with MNPs. We first modified the hydrophobic MNPs with pyrene through a hydrophobic interaction and then formed a complex with PANI. The pyrene-induced π-π interactions between the pyrene molecules on the MNPs and PANI reduced the affinity between the PANI molecules, and the strong affinity between the PANI molecules and MNPs rendered stable nanocomplexes of MPANs. Finally, Cetuximab-conjugated MPANs were fully tested for simultaneous diagnosis by magnetic resonance imaging (MRI) from superparamagnetic MnFe2O4 and photothermal ablation therapy from the near-infrared absorbing characteristics of PANI in epidermal growth factor receptor (EGFR) overexpressed cancer cells (A-431 cells) in vitro.
| Original language | English |
|---|---|
| Pages (from-to) | 3740-3747 |
| Number of pages | 8 |
| Journal | European Journal of Inorganic Chemistry |
| Volume | 2015 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - 2015 Aug 1 |
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All Science Journal Classification (ASJC) codes
- Inorganic Chemistry
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Synthesis of Stable Magnetic Polyaniline Nanohybrids with Pyrene as a Cross-Linker for Simultaneous Diagnosis by Magnetic Resonance Imaging and Photothermal Therapy. / Lee, Taeksu; Bang, Doyeon; Park, Yeonji; Chang, Young Wook; Kang, Byunghoon; Kim, Jinyoung; Suh, Jin Suck; Huh, Yong Min; Haam, Seungjoo.
In: European Journal of Inorganic Chemistry, Vol. 2015, No. 22, 01.08.2015, p. 3740-3747.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis of Stable Magnetic Polyaniline Nanohybrids with Pyrene as a Cross-Linker for Simultaneous Diagnosis by Magnetic Resonance Imaging and Photothermal Therapy
AU - Lee, Taeksu
AU - Bang, Doyeon
AU - Park, Yeonji
AU - Chang, Young Wook
AU - Kang, Byunghoon
AU - Kim, Jinyoung
AU - Suh, Jin Suck
AU - Huh, Yong Min
AU - Haam, Seungjoo
PY - 2015/8/1
Y1 - 2015/8/1
N2 - We have developed pyrene-modified magnetic polyaniline nanoparticles (MPANs), a hybridization of MnFe2O4 magnetic nanoparticles (MNPs) and polyaniline (PANI) with pyrene as a cross-linker, for diagnosis by simultaneous magnetic resonance (MR) imaging and photothermal therapy. In general, the strong affinity between PANI molecules, owing to interchain hydrogen bonding and the π-π interactions mediated by their aromatic composition, hinders the successful synthesis of complexes of PANI with inorganic materials. To overcome this obstacle, we used pyrene as a cross-linker to synthesize a stable complex of PANI with MNPs. We first modified the hydrophobic MNPs with pyrene through a hydrophobic interaction and then formed a complex with PANI. The pyrene-induced π-π interactions between the pyrene molecules on the MNPs and PANI reduced the affinity between the PANI molecules, and the strong affinity between the PANI molecules and MNPs rendered stable nanocomplexes of MPANs. Finally, Cetuximab-conjugated MPANs were fully tested for simultaneous diagnosis by magnetic resonance imaging (MRI) from superparamagnetic MnFe2O4 and photothermal ablation therapy from the near-infrared absorbing characteristics of PANI in epidermal growth factor receptor (EGFR) overexpressed cancer cells (A-431 cells) in vitro.
AB - We have developed pyrene-modified magnetic polyaniline nanoparticles (MPANs), a hybridization of MnFe2O4 magnetic nanoparticles (MNPs) and polyaniline (PANI) with pyrene as a cross-linker, for diagnosis by simultaneous magnetic resonance (MR) imaging and photothermal therapy. In general, the strong affinity between PANI molecules, owing to interchain hydrogen bonding and the π-π interactions mediated by their aromatic composition, hinders the successful synthesis of complexes of PANI with inorganic materials. To overcome this obstacle, we used pyrene as a cross-linker to synthesize a stable complex of PANI with MNPs. We first modified the hydrophobic MNPs with pyrene through a hydrophobic interaction and then formed a complex with PANI. The pyrene-induced π-π interactions between the pyrene molecules on the MNPs and PANI reduced the affinity between the PANI molecules, and the strong affinity between the PANI molecules and MNPs rendered stable nanocomplexes of MPANs. Finally, Cetuximab-conjugated MPANs were fully tested for simultaneous diagnosis by magnetic resonance imaging (MRI) from superparamagnetic MnFe2O4 and photothermal ablation therapy from the near-infrared absorbing characteristics of PANI in epidermal growth factor receptor (EGFR) overexpressed cancer cells (A-431 cells) in vitro.
UR - http://www.scopus.com/inward/record.url?scp=84938744682&partnerID=8YFLogxK
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U2 - 10.1002/ejic.201500283
DO - 10.1002/ejic.201500283
M3 - Article
AN - SCOPUS:84938744682
VL - 2015
SP - 3740
EP - 3747
JO - Chemische Berichte
JF - Chemische Berichte
SN - 0009-2940
IS - 22
ER -