Synthesis of Stable Magnetic Polyaniline Nanohybrids with Pyrene as a Cross-Linker for Simultaneous Diagnosis by Magnetic Resonance Imaging and Photothermal Therapy

Taeksu Lee, Doyeon Bang, Yeonji Park, Young Wook Chang, Byunghoon Kang, Jinyoung Kim, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have developed pyrene-modified magnetic polyaniline nanoparticles (MPANs), a hybridization of MnFe2O4 magnetic nanoparticles (MNPs) and polyaniline (PANI) with pyrene as a cross-linker, for diagnosis by simultaneous magnetic resonance (MR) imaging and photothermal therapy. In general, the strong affinity between PANI molecules, owing to interchain hydrogen bonding and the π-π interactions mediated by their aromatic composition, hinders the successful synthesis of complexes of PANI with inorganic materials. To overcome this obstacle, we used pyrene as a cross-linker to synthesize a stable complex of PANI with MNPs. We first modified the hydrophobic MNPs with pyrene through a hydrophobic interaction and then formed a complex with PANI. The pyrene-induced π-π interactions between the pyrene molecules on the MNPs and PANI reduced the affinity between the PANI molecules, and the strong affinity between the PANI molecules and MNPs rendered stable nanocomplexes of MPANs. Finally, Cetuximab-conjugated MPANs were fully tested for simultaneous diagnosis by magnetic resonance imaging (MRI) from superparamagnetic MnFe2O4 and photothermal ablation therapy from the near-infrared absorbing characteristics of PANI in epidermal growth factor receptor (EGFR) overexpressed cancer cells (A-431 cells) in vitro.

Original languageEnglish
Pages (from-to)3740-3747
Number of pages8
JournalEuropean Journal of Inorganic Chemistry
Volume2015
Issue number22
DOIs
Publication statusPublished - 2015 Aug 1

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry

Cite this