Synthesis of sterically hindered ketones from aldehydes via O-silyl oximes

Joong Gon Kim, Mithilesh Kumar Mishra, Doo Ok Jang

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A mild and efficient method to synthesize sterically hindered ketones from aldehydes via O-silyl oximes was developed. Treatment of O-triphenylsilylated oximes with alkyl iodides in the presence of triethyl borane afforded the corresponding ketones.

Original languageEnglish
Pages (from-to)3527-3529
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number27
DOIs
Publication statusPublished - 2012 Jul 4

Bibliographical note

Funding Information:
This work was supported by the Yonsei University. MKM is grateful for a research fellowship from the Yonsei University.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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