A mild and efficient method to synthesize sterically hindered ketones from aldehydes via O-silyl oximes was developed. Treatment of O-triphenylsilylated oximes with alkyl iodides in the presence of triethyl borane afforded the corresponding ketones.
|Number of pages||3|
|Publication status||Published - 2012 Jul 4|
Bibliographical noteFunding Information:
This work was supported by the Yonsei University. MKM is grateful for a research fellowship from the Yonsei University.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry