Synthesis of substituted benzimidazolyl curcumin mimics and their anticancer activity

Ho Bum Woo, Young Woo Eom, Kyu Sang Park, Jungyeob Ham, Chan Mug Ahn, Seokjoon Lee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A novel curcumin mimic library (14a-14h and 15a-15h) possessing variously substituted benzimidazole groups was synthesized through the aldol reaction of (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-en-2-one (7) or (E)-4-(3-hydroxy-4- methoxyphenyl)but-3-en-2-one (13) with diversely substituted benzimidazolyl-2-carbaldehyde (12a-12h). The MTT assay of the cancer cells MCF-7, SH-SY5Y, HEP-G2, and H460 showed that compound 14c with IC 50 of 1.0 and 1.9 μM has a strong inhibitory effect on the growth of SH-SY5Y and Hep-G2 cells, respectively, and that compound 15h with IC 50 of 1.9 μM has a strong inhibitory effect on the growth of MCF-7 cancer cells.

Original languageEnglish
Pages (from-to)933-936
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number2
DOIs
Publication statusPublished - 2012 Jan 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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